製品: TGM2 Mouse Monoclonal Antibody
カタログ: BF8037
タンパク質の説明: Mouse monoclonal antibody to TGM2
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 77kDa; 77kD(Calculated).
ユニプロット: P21980

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製品説明

ソース:
Mouse
アプリケーション:
WB 1:500-1:3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Monoclonal [AFfirm8037(AFP21832)]
特異性:
TGM2 Antibody detects endogenous levels of total TGM2.
コンジュゲート:
Unconjugated.
精製:
Affinity-chromatography.
保存:
Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

ALPHA SUBUNIT; C polypeptide; EC 2.3.2.13; epididymis secretory protein Li 45; G alpha h; G[a]h; Gh CLASS G ALPHA h; GNAH; GNAH G PROTEIN; H POLYPEPTIDE; HEL-S-45; Protein glutamine gamma glutamyltransferase 2; Protein-glutamine gamma-glutamyltransferase 2; TG 2; TG(C); TG2; TGase C; TGase H; TGase-2; TgaseII; TGC; TGC GUANINE NUCLEOTIDE BINDING PROTEIN; TGM2; TGM2_HUMAN; Tissue transglutaminase; Transglutaminase 2; Transglutaminase 2 C polypeptide; Transglutaminase C; Transglutaminase H; Transglutaminase-2; tTG; tTGas;

免疫原

免疫原:

A synthesized peptide derived from human TGM2, corresponding to a region within N-terminal amino acids.

Uniprot:
遺伝子(ID):
タンパク質の説明:
TGM2 an enzyme of the transglutaminase family that catalyzes the crosslinking of proteins and the conjugation of polyamines to proteins. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. . Is the autoantigen in coeliac disease and plays a role in apoptosis, cellular differentiation and matrix stabilisation.
タンパク質配列:
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA

PTMs - P21980 基板として

Site PTM Type Enzyme
A2 Acetylation
C10 S-Nitrosylation
C27 S-Nitrosylation
S56 Phosphorylation
S60 Phosphorylation
C98 S-Nitrosylation
S129 Phosphorylation
C143 S-Nitrosylation
Y159 Phosphorylation
K202 Acetylation
K205 Acetylation
S212 Phosphorylation
S215 Phosphorylation P17612 (PRKACA)
S216 Phosphorylation P17612 (PRKACA)
Y219 Phosphorylation
C230 S-Nitrosylation
Y245 Phosphorylation
S250 Phosphorylation
C269 S-Nitrosylation
C277 S-Nitrosylation
C285 S-Nitrosylation
Y315 Phosphorylation
C336 S-Nitrosylation
T368 Phosphorylation
Y369 Phosphorylation
C370 S-Nitrosylation
C371 S-Nitrosylation
S415 Phosphorylation
S419 Phosphorylation
S427 Phosphorylation
K464 Ubiquitination
C524 S-Nitrosylation
S538 Phosphorylation
S541 Phosphorylation
C545 S-Nitrosylation
C554 S-Nitrosylation
Y575 Phosphorylation
Y583 Phosphorylation
K590 Ubiquitination
S608 Phosphorylation
C620 S-Nitrosylation
K649 Ubiquitination
K672 Acetylation

PTMs - P21980 酵素として

Substrate Site Source
P68431 (HIST1H3J) S11 Uniprot

研究背景

機能:

Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins.

サブユニット構造:

Monomer.

タンパク質ファミリー:

Belongs to the transglutaminase superfamily. Transglutaminase family.

研究領域

· Human Diseases > Neurodegenerative diseases > Huntington's disease.

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