AKAP7 Antibody - #DF15787

(1)  
製品: AKAP7 Antibody
カタログ: DF15787
タンパク質の説明: Rabbit polyclonal antibody to AKAP7
アプリケーション: IF/ICC
反応性: Human
分子量: 11kD(Calculated).
ユニプロット: O43687

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
AKAP7 Antibody detects endogenous levels of AKAP7.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.

免疫原

免疫原:

A synthesized peptide derived from human AKAP7.

Uniprot:

O43687(AKA7A_HUMAN) >>Visit HPA database.

遺伝子(ID):
AKAP7(9465)
発現特異性:
O43687 AKA7A_HUMAN:

Expressed in brain, heart, lung, pancreas and skeletal muscle.

タンパク質配列:
MGQLCCFPFSRDEGKISELESSSSAVLQRYSKDIPSWSSGEKNGGEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNENNRK

研究背景

機能:

Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.

細胞の位置付け:

Lateral cell membrane>Lipid-anchor.
Note: Targeted predominantly to the lateral membrane.

Apical cell membrane>Lipid-anchor.
Note: Targeted predominantly to the apical membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in brain, heart, lung, pancreas and skeletal muscle.

Restrictive clause

 

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