MARCH4 Antibody - #DF15770

製品: MARCH4 Antibody
カタログ: DF15770
タンパク質の説明: Rabbit polyclonal antibody to MARCH4
アプリケーション: ELISA(peptide)
反応性: Human, Mouse
分子量: 46kD(Calculated).
ユニプロット: Q9P2E8

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MS Report
HPLC Report
MSDS
説明書
COA
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WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
MARCH4 Antibody detects endogenous levels of MARCH4.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

BC056494; E3 ubiquitin protein ligase MARCH4; KIAA1399; MARCH 4; MARCH IV; Membrane associated RING CH protein IV; Membrane associated ring finger (C3HC4) 4; Membrane associated RING finger protein 4; MGC104908; mKIAA1399; RING finger protein 174; RNF174;

免疫原

免疫原:

A synthesized peptide derived from human MARCH4.

Uniprot:

Q9P2E8(MARH4_HUMAN) >>Visit HPA database.

遺伝子(ID):
MARCH4(57574)
発現特異性:
Q9P2E8 MARH4_HUMAN:

Expressed in brain and placenta.

タンパク質配列:
MLMPLCGLLWWWWCCCSGWYCYGLCAPAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQAPLPMHGDPQPPGLAANNTLPALGAGGWAGWRGPREVVGREPPPVPPPPPLPPSSVEDDWGGPATEPPASLLSSASSDDFCKEKTEDRYSLGSSLDSGMRTPLCRICFQGPEQGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAISLTVIEKVQVAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCIGLIIHEGPSVYRIFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSEEETAGTPAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVTTV

研究背景

機能:

E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

細胞の位置付け:

Golgi apparatus membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in brain and placenta.

タンパク質ファミリー:

The RING-CH-type zinc finger domain is required for E3 ligase activity.

Restrictive clause

 

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