MARCH5 Antibody - #DF15768
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
E3 ubiquitin-protein ligase MARCH5; FLJ20445; MARCH-V; MARCH5; MARH5_HUMAN; Membrane-associated ring finger (C3HC4) 5; Membrane-associated RING finger protein 5; Membrane-associated RING-CH protein V; Mitochondrial ubiquitin ligase; MITOL; RING finger protein 153; RNF153;
免疫原
A synthesized peptide derived from human MARCH5.
Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle.
- Q9NX47 MARH5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
研究背景
Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.
Autoubiquitinated leading to degradation (short half-life).
Mitochondrion outer membrane>Multi-pass membrane protein. Endoplasmic reticulum membrane>Multi-pass membrane protein.
Note: Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301).
Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle.
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Restrictive clause
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