NMRK2 Antibody - #DF15767
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
2310015C21Rik,; Integrin beta 1 binding protein 3; Integrin beta-1-binding protein 3; Itgb1bp3; MGC126624; MIBP; Muscle integrin binding protein; Muscle integrin-binding protein; Muscle specific beta 1 integrin binding protein; Nicotinamide riboside kinase 2; Nicotinic acid riboside kinase 2; NmR K 2; NmR-K 2; NRK 2; NRK2; NRK2_HUMAN; Ribosylnicotinamide kinase 2; Ribosylnicotinic acid kinase 2; RNK 2;
免疫原
A synthesized peptide derived from human NMRK2.
Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta.
- Q9NPI5 NRK2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKLIVGIGGMTNGGKTTLTNSLLRALPNCCVIHQDDFFKPQDQIAVGEDGFKQWDVLESLDMEAMLDTVQAWLSSPQKFARAHGVSVQPEASDTHILLLEGFLLYSYKPLVDLYSRRYFLTVPYEECKWRRSTRNYTVPDPPGLFDGHVWPMYQKYRQEMEANGVEVVYLDGMKSREELFREVLEDIQNSLLNRSQESAPSPARPARTQGPGRGCGHRTARPAASQQDSM
研究背景
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
Predominantly expressed in skeletal muscle and, at a much lower level, in the heart (at protein level). No expression in brain, kidney, liver, lung, pancreas nor placenta.
Monomer (By similarity). Interacts with ITGB1 alone or when associated with alpha-7, but not with alpha-5.
Belongs to the uridine kinase family. NRK subfamily.
研究領域
· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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