DHX33 Antibody - #DF15719
| 製品: | DHX33 Antibody |
| カタログ: | DF15719 |
| タンパク質の説明: | Rabbit polyclonal antibody to DHX33 |
| アプリケーション: | ELISA(peptide) |
| 反応性: | Human, Mouse |
| 分子量: | 79kD(Calculated). |
| ユニプロット: | Q9H6R0 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
DDX33; DEAD box polypeptide 33; DEAD/H (Asp Glu Ala Asp/His) box polypeptide 33; DEAH (Asp Glu Ala His) box polypeptide 33; DEAH box protein 33; FLJ21972;
免疫原
A synthesized peptide derived from human DHX33.
- Q9H6R0 DHX33_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MPEEAGFPPAKRFRPGSGPPSRAGSFPPGRQVVMLLTAGSGGRGGGGGRRQQPPLAQPSASPYPEAVELQRRSLPIFQARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFDDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQVFYTKQPQNDYLHAALVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPAMLVLPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALEHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSEGDHMTLLNIYRTFKNLGGNKDWCKENFVNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVESVRRCLAHSLFMSTAELQPDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTELLYTNKCYMRDLCVIDAQWLYEAAPEYFRRKLRTARN
研究背景
Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment. In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation. Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells. Required for NLRP3 activation induced by viral dsRNA and bacterial RNA. In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity).
Ubiquitinated, leading to its degradation by the proteasome. Deubiquitinated by USP36.
Nucleus>Nucleolus. Nucleus>Nucleoplasm. Cytoplasm. Nucleus. Inflammasome.
Note: Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions (PubMed:21930779). Upon dsRNA-binding, localizes in the inflammasome (PubMed:23871209).
Interacts with UBTF. Interacts with DDX3X, EIF3G and EIF3H; the interaction is independent of RNA. Interacts (via HA2 region and Helicase C-terminal domain) with the components of the large ribosomal subunit RPL3, RPL7, RPL26 and RPL27. Interacts (via DEAH box) with NLRP3 (via NACHT domain). Binds to mRNA. Binds to double-stranded RNA (via the helicase C-terminal domain). Interacts (via the helicase C-terminal domain) with MAVS (By similarity).
Belongs to the DEAD box helicase family. DEAH subfamily.
研究領域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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