| 製品: | UBXN4 Antibody |
| カタログ: | DF15685 |
| タンパク質の説明: | Rabbit polyclonal antibody to UBXN4 |
| アプリケーション: | WB ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 57kD(Calculated). |
| ユニプロット: | Q92575 |
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
Erasin; FLJ23318; KIAA0242; KIAA2042; UBX domain containing 1; UBX domain containing 2; UBX domain containing protein 2; UBXD 2; UBXD2; UBXDC 1; UBXDC1;
免疫原
A synthesized peptide derived from human UBXN4.
Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
- Q92575 UBXN4_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLWFQGAIPAAIATAKRSGAVFVVFVAGDDEQSTQMAASWEDDKVTEASSNSFVAIKIDTKSEACLQFSQIYPVVCVPSSFFIGDSGIPLEVIAGSVSADELVTRIHKVRQMHLLKSETSVANGSQSESSVSTPSASFEPNNTCENSQSRNAELCEIPPTSDTKSDTATGGESAGHATSSQEPSGCSDQRPAEDLNIRVERLTKKLEERREEKRKEEEQREIKKEIERRKTGKEMLDYKRKQEEELTKRMLEERNREKAEDRAARERIKQQIALDRAERAARFAKTKEEVEAAKAAALLAKQAEMEVKRESYARERSTVARIQFRLPDGSSFTNQFPSDAPLEEARQFAAQTVGNTYGNFSLATMFPRREFTKEDYKKKLLDLELAPSASVVLLPAGRPTASIVHSSSGDIWTLLGTVLYPFLAIWRLISNFLFSNPPPTQTSVRVTSSEPPNPASSSKSEKREPVRKRVLEKRGDDFKKEGKIYRLRTQDDGEDENNTWNGNSTQQM
研究背景
Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.
Endoplasmic reticulum membrane>Peripheral membrane protein. Nucleus envelope.
Note: Both the N- and the C-terminus face the cytosol. Also found in the nucleus envelope contiguous to the ER.
Expressed in many tissues, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Accumulates in Alzheimer disease-afflicted brains (at protein level).
The UBX domain is required for interaction with VCP.
The intramembrane domain also contains the signal for ER targeting.
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