製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
A6 related protein; A6-related protein; A6r; A6RP; hA6RP; MSTP011; Protein tyrosine kinase 9 like; Protein tyrosine kinase 9-like; PTK 9L; PTK9L; PTK9L protein tyrosine kinase 9 like; TWF 2; Twf2; TWF2_HUMAN; Twinfilin 1 like protein; Twinfilin 2; Twinfilin actin binding protein homolog 2; Twinfilin like protein; Twinfilin-1-like protein; Twinfilin-2; Twinfilin2;
免疫原
A synthesized peptide derived from human TWF2.
- Q6IBS0 TWF2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAHQTGIHATEELKEFFAKARAGSVRLIKVVIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQQPCYLLYRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSFAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKMVNYIQMKLDLERETIELVHTEPTDVAQLPSRVPRDAARYHFFLYKHTHEGDPLESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFHLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGDDS
研究背景
Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity).
In vitro, phosphorylated by PRKCZ, CK2 and SRC.
Cytoplasm>Cytoskeleton. Cytoplasm>Perinuclear region. Cell projection>Stereocilium.
Note: Perinuclear and G-actin-rich cortical actin structure sublocalization.
Ubiquitously expressed (at protein level).
Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.
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