製品: PAPSS2 Antibody
カタログ: DF15364
タンパク質の説明: Rabbit polyclonal antibody to PAPSS2
アプリケーション: WB IHC IF/ICC
反応性: Human, Mouse
分子量: 70kD(Calculated).
ユニプロット: O95340

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製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200, IF/ICC 1:100-1:500, WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
PAPSS2 Antibody detects endogenous levels of PAPSS2.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

3 prime phosphoadenosine 5 prime phosphosulfate synthase 2; 3' phosphoadenosine 5' phosphosulfate synthase 2; ATP sulfurylase/adenosine 5' phosphosulfate kinase; ATP SULFURYLASE/ADENOSINE 5-PRIME PHOSPHOSULFATE KINASE 2; ATP sulfurylase/APS kinase 2; ATPSK2; Bifunctional 3' phosphoadenosine 5' phosphosulfate synthase 2; Bifunctional 3' phosphoadenosine 5' phosphosulfate synthethase 2; PAPS synthase 2; PAPS synthetase 2; PAPSS 2; PHOSPHOADENOSINE-PHOSPHOSULFATE SYNTHETASE 2; SK 2; SK2; Sulfurylase kinase 2;

免疫原

免疫原:

A synthesized peptide derived from human PAPSS2.

Uniprot:
遺伝子(ID):
発現特異性:
O95340 PAPS2_HUMAN:

Expressed in cartilage and adrenal gland.

タンパク質配列:
MSGIKKQKTENQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNRNLGFSPGDREENIRRIAEVAKLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPERVLKTNLSTVSDCVHQVVELLQEQNIVPYTIIKDIHELFVPENKLDHVRAEAETLPSLSITKLDLQWVQVLSEGWATPLKGFMREKEYLQVMHFDTLLDDGVINMSIPIVLPVSAEDKTRLEGCSKFVLAHGGRRVAILRDAEFYEHRKEERCSRVWGTTCTKHPHIKMVMESGDWLVGGDLQVLEKIRWNDGLDQYRLTPLELKQKCKEMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLDWRMKQHAAVLEEGVLDPKSTIVAIFPSPMLYAGPTEVQWHCRSRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKAKKAMDFYDPARHNEFDFISGTRMRKLAREGENPPDGFMAPKAWKVLTDYYRSLEKN

研究背景

機能:

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. May have an important role in skeletogenesis during postnatal growth (By similarity).

組織特異性:

Expressed in cartilage and adrenal gland.

タンパク質ファミリー:

In the N-terminal section; belongs to the APS kinase family.

In the C-terminal section; belongs to the sulfate adenylyltransferase family.

研究領域

· Metabolism > Nucleotide metabolism > Purine metabolism.

· Metabolism > Metabolism of other amino acids > Selenocompound metabolism.

· Metabolism > Energy metabolism > Sulfur metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

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