RNF13 Antibody - #DF15320

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製品: RNF13 Antibody
カタログ: DF15320
タンパク質の説明: Rabbit polyclonal antibody to RNF13
アプリケーション: ELISA(peptide)
反応性: Human, Mouse, Rat
分子量: 43kD(Calculated).
ユニプロット: O43567

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#DF15320-BP

RNF13 Peptide

1mg
関連ダウンロード
Antigen/Blocking Peptide MS Report
Antigen/Blocking Peptide HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
クローナリティ:
Polyclonal
特異性:
RNF13 Antibody detects endogenous levels of RNF13.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

E3 ubiquitin-protein ligase RNF13; FLJ93817; MGC13689; RING finger protein 13; Ring zinc finger protein; RNF 13; Rnf13; RNF13_HUMAN; RZF;

免疫原

免疫原:

A synthesized peptide derived from human RNF13.

Uniprot:

O43567(RNF13_HUMAN) >>Visit HPA database.

遺伝子(ID):
RNF13(11342)
発現特異性:
O43567 RNF13_HUMAN:

Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level).

タンパク質配列:
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFDDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPVKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIEVLKKIDIPSVFIGESSANSLKDEFTYEKGGHLILVPEFSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRARRNRLRKDQLKKLPVHKFKKGDEYDVCAICLDEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENEVTEHTPLLRPLASVSAQSFGALSESRSHQNMTESSDYEEDDNEDTDSSDAENEINEHDVVVQLQPNGERDYNIANTV

研究背景

機能:

E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA.

PTMs:

Auto-ubiquitinated.

細胞の位置付け:

Endoplasmic reticulum membrane. Golgi apparatus membrane. Late endosome membrane>Single-pass membrane protein. Lysosome membrane. Nucleus inner membrane.
Note: Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Widely expressed (at protein level). In normal pancreas, expressed in islets, but not in ducts, nor in acini (at protein level).

タンパク質ファミリー:

The RING-type zinc finger domain is required for E3 ligase activity and for promoting ER stress-induced JNK activation and apoptosis.

Restrictive clause

 

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