Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
CGI 25; CGI25; CGI25 protein; eNOS interacting protein; Nitric oxide synthase interacting protein;
免疫原
A synthesized peptide derived from human NOSIP.
Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
- Q9Y314 NOSIP_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MTRHGKNCTAGAVYTYHEKKKDTAASGYGTQNIRLSRDAVKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKKEIARQMKAYEKQRGTRREEQKELQRAASQDHVRGFLEKESAIVSRPLNPFTAKALSGTSPDDVQPGPSVGPPSKDKDKVLPSFWIPSLTPEAKATKLEKPSRTVTCPMSGKPLRMSDLTPVHFTPLDSSVDRVGLITRSERYVCAVTRDSLSNATPCAVLRPSGAVVTLECVEKLIRKDMVDPVTGDKLTDRDIIVLQRGGTGFAGSGVKLQAEKSRPVMQA
研究背景
E3 ubiquitin-protein ligase that is essential for proper development of the forebrain, the eye, and the face. Catalyzes monoubiquitination of serine/threonine-protein phosphatase 2A (PP2A) catalytic subunit PPP2CA/PPP2CB (By similarity). Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.
Cytoplasm. Nucleus.
Note: Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.
Belongs to the NOSIP family.
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