WRNIP1 Antibody - #DF14889
| 製品: | WRNIP1 Antibody |
| カタログ: | DF14889 |
| タンパク質の説明: | Rabbit polyclonal antibody to WRNIP1 |
| アプリケーション: | WB ELISA(peptide) |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 72kD(Calculated). |
| ユニプロット: | Q96S55 |
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
ATPase WRNIP 1; ATPase WRNIP1; bA420G6.2; FLJ22526; Putative helicase RUVBL; RP11 420G6.2; Werner helicasae interacting protein 1; Werner helicasae interacting protein; Werner helicase interacting protein isoform 2; Werner helicase-interacting protein 1; WHIP; WRIP1_HUMAN; WRNIP 1; WRNIP; Wrnip1;
免疫原
A synthesized peptide derived from human WRNIP1.
- Q96S55 WRIP1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPGRKGSGKRPAAAAAAGSASPRSWDEAEAQEEEEAVGDGDGDGDADADGEDDPGHWDADAAEAATAFGASGGGRPHPRALAAEEIRQMLQGKPLADTMRPDTLQDYFGQSKAVGQDTLLRSLLETNEIPSLILWGPPGCGKTTLAHIIASNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNSSSEPAMFIEDKAVDTLAYLSDGDARAGLNGLQLAVLARLSSRKMFCKKSGQSYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKSMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALTQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRNHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQEYLPEELRGVDFFKQRRC
研究背景
Functions as a modulator of initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. In the presence of ATP, stimulation of DNA polymerase delta-mediated DNA synthesis is decreased. Plays also a role in the innate immune defense against viruses. Stabilizes the RIG-I/DDX58 dsRNA interaction and promotes RIG-I/DDX58 'Lys-63'-linked polyubiquitination. In turn, RIG-I/DDX58 transmits the signal through mitochondrial MAVS.
Sumoylated with SUMO1 and SUMO2/3.
Nucleus. Cytoplasm.
Note: Colocalizes with WRN in granular structures in the nucleus.
Ubiquitously expressed.
The UBZ4-type zinc finger binds ubiquitin.
Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.