Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
ADP ribosyltransferase diphtheria toxin like 15; ADP-ribosyltransferase diphtheria toxin-like 15; ARTD 15; ARTD15; C15orf30; Chromosome 15 open reading frame 30; EC 2.4.2.30; FLJ20509; FLJ25281; mono [ADP-ribose] polymerase PARP16; mono ADP ribose polymerase PARP16; PAR16_HUMAN; PARP 16; PARP-16; Parp16; pART 15; pART15; Poly (ADP ribose) polymerase family member 16; Poly [ADP ribose] polymerase 16; Poly [ADP-ribose] polymerase 16; poly ADP ribose polymerase 16;
免疫原
A synthesized peptide derived from human PARP16.
- Q8N5Y8 PAR16_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR
研究背景
Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes. May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors. May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor. May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases.
Auto-mono-ADP-ribosylated.
Endoplasmic reticulum membrane>Single-pass type IV membrane protein.
The N-terminal PARP alpha-helical domain is regulatory, it packs against the catalytic domain, and may relay effector-binding event to the NAD-binding site.
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