TSPAN33 Antibody - #DF14701
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
1300010A20Rik; AI035228; hPen; MGC30714; MGC50844; PEN; Penumbra; Proerythroblast new membrane; RGD1560915; Tetraspanin-33; TSN33; TSN33_HUMAN; Tspan-33; TSPAN33; Tspan33 tetraspanin 33;
免疫原
A synthesized peptide derived from human TSPAN33.
- Q86UF1 TSN33_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MARRPRAPAASGEEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQILVNQIKDQIKLQLYNQQHRADPWY
研究背景
Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10. Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity. Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7.
Cell membrane>Multi-pass membrane protein. Cell junction>Adherens junction. Cytoplasm.
Note: Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction.
Predominantly expressed in erythroblasts.
Belongs to the tetraspanin (TM4SF) family.
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