ANTXR2 Antibody - #DF14434
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
2310046B19Rik; Anthrax toxin receptor 2; ANTR2_HUMAN; Antxr2; AW561899; Capillary morphogenesis gene 2 protein; Capillary morphogenesis protein 2; CMG 2; CMG-2; CMG2; FLJ31074; HFS; ISH; JHF; MGC111533; MGC45856;
免疫原
A synthesized peptide derived from Human ANTXR2.
Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
- P58335 ANTR2_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVAERSPARSPGSWLFPGLWLLVLSGPGGLLRAQEQPSCRRAFDLYFVLDKSGSVANNWIEIYNFVQQLAERFVSPEMRLSFIVFSSQATIILPLTGDRGKISKGLEDLKRVSPVGETYIHEGLKLANEQIQKAGGLKTSSIIIALTDGKLDGLVPSYAEKEAKISRSLGASVYCVGVLDFEQAQLERIADSKEQVFPVKGGFQALKGIINSILAQSCTEILELQPSSVCVGEEFQIVLSGRGFMLGSRNGSVLCTYTVNETYTTSVKPVSVQLNSMLCPAPILNKAGETLDVSVSFNGGKSVISGSLIVTATECSNGIAAIIVILVLLLLLGIGLMWWFWPLCCKVVIKDPPPPPAPAPKEEEEEPLPTKKWPTVDASYYGGRGVGGIKRMEVRWGDKGSTEEGARLEKAKNAVVKIPEETEEPIRPRPPRPKPTHQPPQTKWYTPIKGRLDALWALLRRQYDRVSLMRPQEGDEVCIWECIEKELTA
研究背景
Necessary for cellular interactions with laminin and the extracellular matrix.
Cell membrane>Single-pass type I membrane protein.
Note: Expressed at the cell surface.
Endoplasmic reticulum membrane>Single-pass type I membrane protein.
Note: Expressed predominantly within the endoplasmic reticulum and not at the plasma membrane.
Secreted.
Expressed in prostate, thymus, ovary, testis, pancreas, colon, heart, kidney, lung, liver, peripheral blood leukocytes, placenta, skeletal muscle, small intestine and spleen.
Binds laminin, and possibly also collagen type IV. Binds to the protective antigen (PA) of Bacillus anthracis in a divalent cation-dependent manner, with the following preference: calcium > manganese > magnesium > zinc. Binding of PA leads to heptamerization of the receptor-PA complex.
Binding to PA seems to be effected through the VWA domain.
Belongs to the ATR family.
研究領域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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