SPINK2 Antibody - #DF14268

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製品: SPINK2 Antibody
カタログ: DF14268
タンパク質の説明: Rabbit polyclonal antibody to SPINK2
アプリケーション: IF/ICC
反応性: Human, Mouse, Rat
分子量: 9kD; 9kD(Calculated).
ユニプロット: P20155

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関連ダウンロード
MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
SPINK2 Antibody detects endogenous levels of total SPINK2.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Acrosin-trypsin inhibitor; HUSI-II; ISK2_HUMAN; Serine protease inhibitor Kazal-type 2; SPINK2;

免疫原

免疫原:

A synthesized peptide derived from Human SPINK2.

Uniprot:

P20155(ISK2_HUMAN) >>Visit HPA database.

遺伝子(ID):
SPINK2(6691)
発現特異性:
P20155 ISK2_HUMAN:

Expressed in epididymis (at protein level).

タンパク質配列:
MALSVLRLALLLLAVTFAASLIPQFGLFSKYRTPNCSQYRLPGCPRHFNPVCGSDMSTYANECTLCMKIREGGHNIKIIRNGPC

研究背景

機能:

As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis (By similarity). It also inhibits trypsin.

細胞の位置付け:

Secreted. Cytoplasmic vesicle>Secretory vesicle>Acrosome.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in epididymis (at protein level).

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