HVCN1 Antibody - #DF14252
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
折りたたみ／展開
HV 1; HV1; HVCN 1; HVCN1; HVCN1_HUMAN; Hydrogen voltage gated channel 1; Hydrogen voltage-gated channel 1; Voltage gated hydrogen channel 1; Voltage sensor domain only protein; Voltage sensor domain-only protein; Voltage-gated hydrogen channel 1; VSOP;
免疫原
A synthesized peptide derived from Human HVCN1.
Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.
- Q96D96 HVCN1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATWDEKAVTRRAKVAPAERMSKFLRHFTVVGDDYHAWNINYKKWENEEEEEEEEQPPPTPVSGEEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLFSSHRFQVIIICLVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFVFRLEFFHHKFEILDAVVVVVSFILDIVLLFQEHQFEALGLLILLRLWRVARIINGIIISVKTRSERQLLRLKQMNVQLAAKIQHLEFSCSEKEQEIERLNKLLRQHGLLGEVN
研究背景
Mediates the voltage-dependent proton permeability of excitable membranes. Forms a proton-selective channel through which protons may pass in accordance with their electrochemical gradient. Proton efflux, accompanied by membrane depolarization, facilitates acute production of reactive oxygen species in phagocytosis.
Phosphorylation may enhance channel gating.
Membrane>Multi-pass membrane protein. Cell membrane>Multi-pass membrane protein.
Note: Detected mainly at intracellular membranes upon overexpression in HeLa cells (PuMed:20147290), but not in other cell types.
Enriched in immune tissues, such as lymph nodes, B-lymphocytes, monocytes and spleen.
The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position. Unlike other voltage-gated ion channels it lacks the pore domain.
The C-terminal coiled coil region mediates homodimerization and cooperative channel gating. It is essential for normal subcellular localization.
Belongs to the hydrogen channel family.
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