ZC3H12D Antibody - #DF14171

製品: ZC3H12D Antibody
カタログ: DF14171
タンパク質の説明: Rabbit polyclonal antibody to ZC3H12D
アプリケーション: ELISA(peptide)
反応性: Human
分子量: 55~70kD; 58kD(Calculated).
ユニプロット: A2A288

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human
クローナリティ:
Polyclonal
特異性:
ZC3H12D Antibody detects endogenous levels of total ZC3H12D.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

C6orf95; ZC3H12D; FLJ00361; FLJ46041; MCP induced protein 4; MCP-induced protein 4; MCPIP4; p34; Probable ribonuclease ZC3H12D; TFL; Transformed follicular lymphoma; Tumor suppressor TFL; ZC12D_HUMAN; ZC3H12D; Zinc finger CCCH domain containing protein 12D; Zinc finger CCCH domain-containing protein 12D;

免疫原

免疫原:

A synthesized peptide derived from Human ZC3H12D.

Uniprot:

A2A288(ZC12D_HUMAN) >>Visit HPA database.

遺伝子(ID):
ZC3H12D(340152)
発現特異性:
A2A288 ZC12D_HUMAN:

Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.

タンパク質配列:
MEHPSKMEFFQKLGYDREDVLRVLGKLGEGALVNDVLQELIRTGSRPGALEHPAAPRLVPRGSCGVPDSAQRGPGTALEEDFRTLASSLRPIVIDGSNVAMSHGNKETFSCRGIKLAVDWFRDRGHTYIKVFVPSWRKDPPRADTPIREQHVLAELERQAVLVYTPSRKVHGKRLVCYDDRYIVKVAYEQDGVIVSNDNYRDLQSENPEWKWFIEQRLLMFSFVNDRFMPPDDPLGRHGPSLSNFLSRKPKPPEPSWQHCPYGKKCTYGIKCKFYHPERPHHAQLAVADELRAKTGARPGAGAEEQRPPRAPGGSAGARAAPREPFAHSLPPARGSPDLAALRGSFSRLAFSDDLGPLGPPLPVPACSLTPRLGGPDWVSAGGRVPGPLSLPSPESQFSPGDLPPPPGLQLQPRGEHRPRDLHGDLLSPRRPPDDPWARPPRSDRFPGRSVWAEPAWGDGATGGLSVYATEDDEGDARARARIALYSVFPRDQVDRVMAAFPELSDLARLILLVQRCQSAGAPLGKP

研究背景

機能:

May regulate cell growth likely by suppressing RB1 phosphorylation. May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages. Serve as a tumor suppressor in certain leukemia cells. Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation.

細胞の位置付け:

Cytoplasm>P-body.
Note: Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560).

Cytoplasm.
Note: Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm.

Cytoplasm. Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.

タンパク質ファミリー:

Belongs to the ZC3H12 family.

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