ITIH3 Antibody - #DF14157

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製品: ITIH3 Antibody
カタログ: DF14157
タンパク質の説明: Rabbit polyclonal antibody to ITIH3
アプリケーション: WB IHC IF/ICC
Cited expt.: IHC
反応性: Human, Mouse, Rat
分子量: 100kD(Calculated).
ユニプロット: Q06033

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MS Report
HPLC Report
MSDS
説明書
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WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
ITIH3 Antibody detects endogenous levels of total ITIH3.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

AW108094; H3P; Inter alpha (globulin) inhibitor, H3 polypeptide; Inter alpha inhibitor heavy chain 3; Inter alpha trypsin inhibitor heavy chain H3; Intin3; ITI HC3; ITI heavy chain H3; PAIHC3; Pre alpha-inhibitor, heavy chain 3; Serum derived hyaluronan-associated protein; SHAP;

免疫原

免疫原:

A synthesized peptide derived from Human ITIH3.

Uniprot:

Q06033(ITIH3_HUMAN) >>Visit HPA database.

遺伝子(ID):
ITIH3(3699)
タンパク質配列:
MAFAWWPCLILALLSSLAASGFPRSPFRLLGKRSLPEGVANGIEVYSTKINSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITNFTLTIDGVTYPGNVKEKEVAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSVNVAAGSKVTFELTYEELLKRHKGKYEMYLKVQPKQLVKHFEIEVDIFEPQGISMLDAEASFITNDLLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCTDSLLNGDFTITYDVNRESPGNVQIVNGYFVHFFAPQGLPVVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQEEDYLNFILFSGDVSTWKEHLVQATPENLQEARTFVKSMEDKGMTNINDGLLRGISMLNKAREEHRIPERSTSIVIMLTDGDANVGESRPEKIQENVRNAIGGKFPLYNLGFGNNLNYNFLENMALENHGFARRIYEDSDADLQLQGFYEEVANPLLTGVEMEYPENAILDLTQNTYQHFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEMEKALQERDYIFGNYIERLWAYLTIEQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLTSMVVTKPEDNEDERAIADKPGEDAEATPVSPAMSYLTSYQPPQNPYYYVDGDPHFIIQIPEKDDALCFNIDEAPGTVLRLIQDAVTGLTVNGQITGDKRGSPDSKTRKTYFGKLGIANAQMDFQVEVTTEKITLWNRAVPSTFSWLDTVTVTQDGLSMMINRKNMVVSFGDGVTFVVVLHQVWKKHPVHRDFLGFYVVDSHRMSAQTHGLLGQFFQPFDFKVSDIRPGSDPTKPDATLVVKNHQLIVTRGSQKDYRKDASIGTKVVCWFVHNNGEGLIDGVHTDYIVPNLF

研究背景

機能:

May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.

PTMs:

Heavy chains are linked to bikunin via chondroitin 4-sulfate esterified to the alpha-carboxyl of the C-terminal aspartate after propeptide cleavage.

細胞の位置付け:

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the ITIH family.

参考文献

1). Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study. Heliyon, 2023 (PubMed: 38027820) [IF=4.0]

Application: IHC    Species: human    Sample:

Fig. 5 Validation of placenta differential proteins using IHC. (A) NECTIN1 levels in the placental samples obtained from ICP and control groups (P = 0.0022). (B) SPINT1 levels in the placental samples obtained from ICP and control groups (P < 0.0001). (C) CD320 levels in the placental samples obtained from ICP and control groups (P < 0.0001). (D) ITIH3 levels in the placental samples obtained from ICP and control groups (P < 0.0001). (E) ENPP2 levels in the placental samples obtained from ICP and control groups (P < 0.0001). (F) SERPIND1 levels in the placental samples obtained from ICP and control groups (P < 0.0001); (****P < 0.0001, **P < 0.01). (G–L) IHC staining for NECTIN1, SPINT1, CD320, ITIH3, ENPP2, and SERPIND1 in the placental samples obtained from ICP and control groups ( × 200). IHC, immunohistochemistry; ICP, intrahepatic cholestasis of pregnancy.

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