LOXL1 Antibody - #DF14089

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製品: LOXL1 Antibody
カタログ: DF14089
タンパク質の説明: Rabbit polyclonal antibody to LOXL1
アプリケーション: IHC
Cited expt.: IHC
反応性: Human, Mouse
分子量: 63kD; 63kD(Calculated).
ユニプロット: Q08397

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
クローナリティ:
Polyclonal
特異性:
LOXL1 Antibody detects endogenous levels of total LOXL1.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Lysyl oxidase like 1; LOL; LOXL; Lysyl oxidase homolog 1; Lysyl oxidase like protein 1;

免疫原

免疫原:

A synthesized peptide derived from Human LOXL1.

Uniprot:

Q08397(LOXL1_HUMAN) >>Visit HPA database.

遺伝子(ID):
LOXL1(4016)
発現特異性:
Q08397 LOXL1_HUMAN:

Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina.

タンパク質配列:
MALARGSRQLGALVWGACLCVLVHGQQAQPGQGSDPARWRQLIQWENNGQVYSLLNSGSEYVPAGPQRSESSSRVLLAGAPQAQQRRSHGSPRRRQAPSLPLPGRVGSDTVRGQARHPFGFGQVPDNWREVAVGDSTGMARARTSVSQQRHGGSASSVSASAFASTYRQQPSYPQQFPYPQAPFVSQYENYDPASRTYDQGFVYYRPAGGGVGAGAAAVASAGVIYPYQPRARYEEYGGGEELPEYPPQGFYPAPERPYVPPPPPPPDGLDRRYSHSLYSEGTPGFEQAYPDPGPEAAQAHGGDPRLGWYPPYANPPPEAYGPPRALEPPYLPVRSSDTPPPGGERNGAQQGRLSVGSVYRPNQNGRGLPDLVPDPNYVQASTYVQRAHLYSLRCAAEEKCLASTAYAPEATDYDVRVLLRFPQRVKNQGTADFLPNRPRHTWEWHSCHQHYHSMDEFSHYDLLDAATGKKVAEGHKASFCLEDSTCDFGNLKRYACTSHTQGLSPGCYDTYNADIDCQWIDITDVQPGNYILKVHVNPKYIVLESDFTNNVVRCNIHYTGRYVSATNCKIVQS

研究背景

機能:

Active on elastin and collagen substrates.

PTMs:

The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.

細胞の位置付け:

Secreted>Extracellular space.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in ocular tissues including the iris, ciliary body, lens and optic nerve. Not detected in the retina.

タンパク質ファミリー:

Belongs to the lysyl oxidase family.

参考文献

1). Necroptosis-based glioblastoma prognostic subtypes: implications for TME remodeling and therapy response. Annals of medicine, 2024 (PubMed: 39387496) [IF=4.9]

Application: IHC    Species: human    Sample:

Figure 8. GNI Genes modulates macrophage polarization. (A) Correlation between infiltration of immune cells and individual GNI genes (n = 10) in TCGA GBM cohort. (spearman’s correlation test; Statistical significance is indicated as follows: *p 

Application: WB    Species: human    Sample:

Figure 8. GNI Genes modulates macrophage polarization. (A) Correlation between infiltration of immune cells and individual GNI genes (n = 10) in TCGA GBM cohort. (spearman’s correlation test; Statistical significance is indicated as follows: *p 

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