製品: Phospho-PLD2 (Tyr169) Antibody
カタログ: AF3974
タンパク質の説明: Rabbit polyclonal antibody to Phospho-PLD2 (Tyr169)
アプリケーション: ELISA(peptide)
反応性: Human, Mouse, Rat
分子量: 106kD(Calculated).
ユニプロット: O14939
RRID: AB_2847697

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製品説明

ソース:
Rabbit
アプリケーション:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
Phospho-PLD2 (Tyr169) Antibody detects endogenous levels of PLD2 only when phosphorylated at Tyr169.
RRID:
AB_2847697
引用形式: Affinity Biosciences Cat# AF3974, RRID:AB_2847697.
コンジュゲート:
Unconjugated.
精製:
The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Choline phosphatase 2; EC 3.1.4.4; hPLD 2; hPLD2; mPLD2; Phosphatidylcholine hydrolyzing phospholipase D2; Phosphatidylcholine-hydrolyzing phospholipase D2; Phospholipase D2; PhospholipaseD2; PLD 2; PLD1C; Pld2; PLD2_HUMAN; Pldc; rPLD2;

免疫原

免疫原:

A synthesized peptide derived from human PLD2 around the phosphorylation site of Tyr169.

Uniprot:
遺伝子(ID):
発現特異性:
O14939 PLD2_HUMAN:

Ubiquitous.

タンパク質配列:
MTATPESLFPTGDELDSSQLQMESDEVDTLKEGEDPADRMHPFLAIYELQSLKVHPLVFAPGVPVTAQVVGTERYTSGSKVGTCTLYSVRLTHGDFSWTTKKKYRHFQELHRDLLRHKVLMSLLPLARFAVAYSPARDAGNREMPSLPRAGPEGSTRHAASKQKYLENYLNRLLTMSFYRNYHAMTEFLEVSQLSFIPDLGRKGLEGMIRKRSGGHRVPGLTCCGRDQVCYRWSKRWLVVKDSFLLYMCLETGAISFVQLFDPGFEVQVGKRSTEARHGVRIDTSHRSLILKCSSYRQARWWAQEITELAQGPGRDFLQLHRHDSYAPPRPGTLARWFVNGAGYFAAVADAILRAQEEIFITDWWLSPEVYLKRPAHSDDWRLDIMLKRKAEEGVRVSILLFKEVELALGINSGYSKRALMLLHPNIKVMRHPDQVTLWAHHEKLLVVDQVVAFLGGLDLAYGRWDDLHYRLTDLGDSSESAASQPPTPRPDSPATPDLSHNQFFWLGKDYSNLITKDWVQLDRPFEDFIDRETTPRMPWRDVGVVVHGLPARDLARHFIQRWNFTKTTKAKYKTPTYPYLLPKSTSTANQLPFTLPGGQCTTVQVLRSVDRWSAGTLENSILNAYLHTIRESQHFLYIENQFFISCSDGRTVLNKVGDEIVDRILKAHKQGWCYRVYVLLPLLPGFEGDISTGGGNSIQAILHFTYRTLCRGEYSILHRLKAAMGTAWRDYISICGLRTHGELGGHPVSELIYIHSKVLIADDRTVIIGSANINDRSLLGKRDSELAVLIEDTETEPSLMNGAEYQAGRFALSLRKHCFGVILGANTRPDLDLRDPICDDFFQLWQDMAESNANIYEQIFRCLPSNATRSLRTLREYVAVEPLATVSPPLARSELTQVQGHLVHFPLKFLEDESLLPPLGSKEGMIPLEVWT

PTMs - O14939 基板として

Site PTM Type Enzyme
T29 Phosphorylation
T72 Phosphorylation
S77 Phosphorylation
S79 Phosphorylation
K80 Ubiquitination
T99 Phosphorylation
T100 Phosphorylation
K118 Ubiquitination
S134 Phosphorylation Q00535 (CDK5)
S146 Phosphorylation
T156 Phosphorylation
S161 Phosphorylation
Y169 Phosphorylation
T175 Phosphorylation
Y179 Phosphorylation P00533 (EGFR)
S213 Phosphorylation
S243 Phosphorylation P17252 (PRKCA)
T252 Phosphorylation P17252 (PRKCA)
K292 Methylation
Y296 Phosphorylation P00533 (EGFR)
K388 Methylation
K388 Ubiquitination
Y415 Phosphorylation P52333 (JAK3)
S416 Phosphorylation
T488 Phosphorylation
Y511 Phosphorylation P12931 (SRC)
T566 Phosphorylation Q05655 (PRKCD)
Y573 Phosphorylation
Y578 Phosphorylation
Y580 Phosphorylation
K656 Ubiquitination

研究背景

機能:

May have a role in signal-induced cytoskeletal regulation and/or endocytosis.

PTMs:

Phosphorylated by FGR.

細胞の位置付け:

Membrane>Peripheral membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous.

サブユニット構造:

Interacts with EGFR (By similarity). Interacts with PIP5K1B.

タンパク質ファミリー:

Belongs to the phospholipase D family.

研究領域

· Cellular Processes > Transport and catabolism > Endocytosis.   (View pathway)

· Environmental Information Processing > Signal transduction > Ras signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > cAMP signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Sphingolipid signaling pathway.   (View pathway)

· Environmental Information Processing > Signal transduction > Phospholipase D signaling pathway.   (View pathway)

· Human Diseases > Cancers: Overview > Choline metabolism in cancer.   (View pathway)

· Metabolism > Lipid metabolism > Glycerophospholipid metabolism.

· Metabolism > Lipid metabolism > Ether lipid metabolism.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Immune system > Fc gamma R-mediated phagocytosis.   (View pathway)

· Organismal Systems > Nervous system > Glutamatergic synapse.

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