IREB1 Antibody - #AF6792
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| 製品: | IREB1 Antibody |
| カタログ: | AF6792 |
| タンパク質の説明: | Rabbit polyclonal antibody to IREB1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 80,100kD; 98kD(Calculated). |
| ユニプロット: | P21399 |
| RRID: | AB_2847515 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6792, RRID:AB_2847515.
折りたたみ／展開
ACO 1; ACO1; ACOC_HUMAN; Aconitase 1 soluble; Aconitase; Aconitase1; Aconitate hydratase; ACONS; Citrate hydro lyase; Citrate hydro-lyase; Cytoplasmic aconitate hydratase; Ferritin repressor protein; IRE BP 1; IRE-BP 1; IREB 1; IREB1; IREBP; IREBP1; Iron regulatory protein 1; Iron responsive element binding protein 1; Iron-responsive element-binding protein 1; IRP 1; IRP1; OTTHUMP00000045233;
免疫原
A synthesized peptide derived from human IREB1.
- P21399 ACOC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
PTMs - P21399 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K26 | Ubiquitination | Uniprot | |
| S30 | Phosphorylation | Uniprot | |
| K79 | Ubiquitination | Uniprot | |
| K105 | Ubiquitination | Uniprot | |
| K106 | Ubiquitination | Uniprot | |
| S138 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| K141 | Ubiquitination | Uniprot | |
| K158 | Ubiquitination | Uniprot | |
| Y184 | Phosphorylation | Uniprot | |
| K250 | Ubiquitination | Uniprot | |
| T258 | Phosphorylation | Uniprot | |
| T318 | Phosphorylation | Uniprot | |
| K335 | Ubiquitination | Uniprot | |
| Y336 | Phosphorylation | Uniprot | |
| S383 | Phosphorylation | Uniprot | |
| K386 | Ubiquitination | Uniprot | |
| K387 | Ubiquitination | Uniprot | |
| K396 | Ubiquitination | Uniprot | |
| K400 | Ubiquitination | Uniprot | |
| K455 | Ubiquitination | Uniprot | |
| Y466 | Phosphorylation | Uniprot | |
| S533 | Phosphorylation | Uniprot | |
| K572 | Ubiquitination | Uniprot | |
| K580 | Ubiquitination | Uniprot | |
| K587 | Ubiquitination | Uniprot | |
| K610 | Ubiquitination | Uniprot | |
| K615 | Ubiquitination | Uniprot | |
| S622 | Phosphorylation | Uniprot | |
| T628 | Phosphorylation | Uniprot | |
| K632 | Ubiquitination | Uniprot | |
| S638 | Phosphorylation | Uniprot | |
| K639 | Ubiquitination | Uniprot | |
| K644 | Ubiquitination | Uniprot | |
| S645 | Phosphorylation | Uniprot | |
| S711 | Phosphorylation | P17252 (PRKCA) | Uniprot |
| R713 | Methylation | Uniprot | |
| R721 | Methylation | Uniprot | |
| K736 | Ubiquitination | Uniprot | |
| K772 | Ubiquitination | Uniprot | |
| K785 | Ubiquitination | Uniprot | |
| S799 | Phosphorylation | Uniprot | |
| Y800 | Phosphorylation | Uniprot | |
| S806 | Phosphorylation | Uniprot | |
| K844 | Ubiquitination | Uniprot | |
| K852 | Ubiquitination | Uniprot | |
| K857 | Ubiquitination | Uniprot |
研究背景
Iron sensor. Binds a 4Fe-4S cluster and functions as aconitase when cellular iron levels are high. Functions as mRNA binding protein that regulates uptake, sequestration and utilization of iron when cellular iron levels are low. Binds to iron-responsive elements (IRES) in target mRNA species when iron levels are low. Binding of a 4Fe-4S cluster precludes RNA binding.
Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.
Cytoplasm.
Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).
Belongs to the aconitase/IPM isomerase family.
研究領域
· Metabolism > Carbohydrate metabolism > Citrate cycle (TCA cycle).
· Metabolism > Carbohydrate metabolism > Glyoxylate and dicarboxylate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
· Metabolism > Global and overview maps > 2-Oxocarboxylic acid metabolism.
· Metabolism > Global and overview maps > Biosynthesis of amino acids.
参考文献
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