SOD2/MnSOD Antibody - #AF6751
| 製品: | SOD2/MnSOD Antibody |
| カタログ: | AF6751 |
| タンパク質の説明: | Rabbit polyclonal antibody to SOD2/MnSOD |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 分子量: | 25kD(Calculated). |
| ユニプロット: | P04179 |
| RRID: | AB_2847474 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF6751, RRID:AB_2847474.
折りたたみ／展開
Indophenoloxidase B; IPO B; IPOB; Manganese containing superoxide dismutase; Manganese SOD; Manganese superoxide dismutase; Mangano superoxide dismutase; Mn SOD; Mn superoxide dismutase; MNSOD; MVCD6; SOD 2; SOD2; SODM_HUMAN; Superoxide dismutase [Mn] mitochondrial; Superoxide dismutase [Mn], mitochondrial; Superoxide dismutase 2 mitochondrial;
免疫原
A synthesized peptide derived from human SOD2/MnSOD.
- P04179 SODM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MLSRAVCGTSRQLAPVLGYLGSRQKHSLPDLPYDYGALEPHINAQIMQLHHSKHHAAYVNNLNVTEEKYQEALAKGDVTAQIALQPALKFNGGGHINHSIFWTNLSPNGGGEPKGELLEAIKRDFGSFDKFKEKLTAASVGVQGSGWGWLGFNKERGHLQIAACPNQDPLQGTTGLIPLLGIDVWEHAYYLQYKNVRPDYLKAIWNVINWENVTERYMACKK
PTMs - P04179 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K53 | Acetylation | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| K68 | Acetylation | Uniprot | |
| T79 | Phosphorylation | Uniprot | |
| S106 | Phosphorylation | P06493 (CDK1) , P11802 (CDK4) | Uniprot |
| K122 | Acetylation | Uniprot | |
| K122 | Ubiquitination | Uniprot | |
| S127 | Phosphorylation | Uniprot | |
| K130 | Acetylation | Uniprot | |
| K130 | Methylation | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| K132 | Acetylation | Uniprot | |
| K221 | Acetylation | Uniprot |
研究背景
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.
Mitochondrion matrix.
Homotetramer.
Belongs to the iron/manganese superoxide dismutase family.
研究領域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Environmental Information Processing > Signal transduction > FoxO signaling pathway. (View pathway)
· Human Diseases > Neurodegenerative diseases > Huntington's disease.
· Organismal Systems > Aging > Longevity regulating pathway. (View pathway)
· Organismal Systems > Aging > Longevity regulating pathway - multiple species. (View pathway)
Restrictive clause
Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.
For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.