Tryptophan Hydroxylase Antibody - #AF6714

製品: Tryptophan Hydroxylase Antibody
カタログ: AF6714
タンパク質の説明: Rabbit polyclonal antibody to Tryptophan Hydroxylase
アプリケーション: ELISA(peptide)
反応性: Human, Mouse, Rat
分子量: 55kD; 51kD(Calculated).
ユニプロット: P17752
RRID: AB_2847437

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MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
ELISA(peptide) 1:20000-1:40000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
Tryptophan Hydroxylase Antibody detects endogenous levels of total Tryptophan Hydroxylase.
RRID:
AB_2847437
引用形式: Affinity Biosciences Cat# AF6714, RRID:AB_2847437.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Indoleacetic acid 5 hydroxylase; L tryptophan hydroxylase; MGC119994; TPH 1; TPH; TPH1; TPH1_HUMAN; TPRH; TRPH; Tryptophan 5 hydroxylase 1; Tryptophan 5 monooxygenase 1; Tryptophan 5 monooxygenase; Tryptophan 5-hydroxylase 1; Tryptophan 5-monooxygenase 1; Tryptophan hydroxylase 1;

免疫原

免疫原:

A synthesized peptide derived from human Tryptophan Hydroxylase.

Uniprot:

P17752(TPH1_HUMAN) >>Visit HPA database.

遺伝子(ID):
TPH1(7166)
発現特異性:
P17752 TPH1_HUMAN:

Isoform 2 seems to be less widely expressed than isoform 1.

タンパク質配列:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI

PTMs - P17752 基板として

Site PTM Type Enzyme
K33 Acetylation
S58 Phosphorylation
T225 Phosphorylation
S228 Phosphorylation
S260 Phosphorylation
Y373 Phosphorylation
Y401 Phosphorylation
Y404 Phosphorylation

研究背景

組織特異性:

Isoform 2 seems to be less widely expressed than isoform 1.

サブユニット構造:

Homotetramer.

タンパク質ファミリー:

Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.

研究領域

· Metabolism > Amino acid metabolism > Tryptophan metabolism.

· Metabolism > Metabolism of cofactors and vitamins > Folate biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

· Organismal Systems > Nervous system > Serotonergic synapse.

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