TIM 4 Antibody - #DF13636

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製品: TIM 4 Antibody
カタログ: DF13636
タンパク質の説明: Rabbit polyclonal antibody to TIM 4
アプリケーション: WB IHC IF/ICC
Cited expt.: WB, IHC
反応性: Human, Mouse, Rat
分子量: 41kDa(Observed); 42kD(Calculated).
ユニプロット: Q96H15
RRID: AB_2846655

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#DF13636-BP

TIM 4 Peptide

1mg
関連ダウンロード
Antigen/Blocking Peptide MS Report
Antigen/Blocking Peptide HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
TIM 4 Antibody detects endogenous levels of total TIM 4.
RRID:
AB_2846655
引用形式: Affinity Biosciences Cat# DF13636, RRID:AB_2846655.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

SMUCKLER; Spleen, mucin-containing, knockout of lymphotoxin protein; T cell immunoglobulin and mucin domain containing protein 4; T-cell immunoglobulin and mucin domain containing 4; T-cell immunoglobulin and mucin domain containing molecule; T-cell immunoglobulin and mucin domain-containing protein 4; T-cell immunoglobulin and mucin domains-containing protein 4; T-cell membrane protein 4; TIM-4; Tim4; TIMD 4; TIMD-4; Timd4; TIMD4_HUMAN;

免疫原

免疫原:

A synthesized peptide derived from human TIM 4, corresponding to a region within the internal amino acids.

Uniprot:

Q96H15(TIMD4_HUMAN) >>Visit HPA database.

遺伝子(ID):
TIMD4(91937)
タンパク質配列:
MSKEPLILWLMIEFWWLYLTPVTSETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCPYSGCKEALIRTDGMRVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWFNDVKINVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTTPDLTTGTPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPILTAESETVLPSDSWSSVESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDSVSSPQPGASDTAVPEQNKTTKTGQMDGIPMSMKNEMPISQLLMIIAPSLGFVLFALFVAFLLRGKLMETYCSQKHTRLDYIGDSKNVLNDVQHGREDEDGLFTL

研究背景

機能:

Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Involved in regulating T-cell proliferation and lymphotoxin signaling. Ligand for HAVCR1/TIMD1 (By similarity).

細胞の位置付け:

Membrane>Single-pass type I membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Recognizes phosphatidyl serine via its immunoglobulin domain.

Belongs to the immunoglobulin superfamily. TIM family.

参考文献

1). Identification and validation of efferocytosis-related biomarkers for the diagnosis of metabolic dysfunction-associated steatohepatitis based on bioinformatics analysis and machine learning. Frontiers in immunology, 2024 (PubMed: 39497821) [IF=7.3]

Application: WB    Species: Mouse    Sample:

Figure 9. Construction of MASH mice model and validation of hub genes. (A) The HE and Oil Red staining in Control and MASH mice. Scale bar, 100 μm. (B, C) serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level mice model. (D) Blood glucose levels after 6 h of fasting. (E, F) Relative mRNA levels of Trem2 and Timd4 in MASH and Control mice, standardized by Gapdh. (G) Immunohistochemical staining of TREM2 and TIMD4 in MASH and Control mice. (H-J) Relative protein level of TREM2 and TIMD4 in MASH and Control mice, standardized by β-tubulin. ** indicates P

Application: IHC    Species: Mouse    Sample:

Figure 9. Construction of MASH mice model and validation of hub genes. (A) The HE and Oil Red staining in Control and MASH mice. Scale bar, 100 μm. (B, C) serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) level mice model. (D) Blood glucose levels after 6 h of fasting. (E, F) Relative mRNA levels of Trem2 and Timd4 in MASH and Control mice, standardized by Gapdh. (G) Immunohistochemical staining of TREM2 and TIMD4 in MASH and Control mice. (H-J) Relative protein level of TREM2 and TIMD4 in MASH and Control mice, standardized by β-tubulin. ** indicates P
2). Anti-Tim4 Grafting Strongly Hydrophilic Metal–Organic Frameworks Immunoaffinity Flake for High-Efficiency Capture and Separation of Exosomes. ANALYTICAL CHEMISTRY, 2021 (PubMed: 33851819) [IF=6.7]

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Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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