TEM8 Antibody - #DF13424
| 製品: | TEM8 Antibody |
| カタログ: | DF13424 |
| タンパク質の説明: | Rabbit polyclonal antibody to TEM8 |
| アプリケーション: | WB IF/ICC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog, Chicken |
| 分子量: | 62kDa; 63kD(Calculated). |
| ユニプロット: | Q9H6X2 |
| RRID: | AB_2846443 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13424, RRID:AB_2846443.
折りたたみ／展開
Anthrax toxin receptor 1; ANTR1_HUMAN; Antxr1; ATR; Tumor endothelial marker 8;
免疫原
Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
- Q9H6X2 ANTR1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MATAERRALGIGFQWLSLATLVLICAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHKFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENRQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFSVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPAEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNNQPAKYPLNNAYHTSSPPPAPIYTPPPPAPHCPPPPPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9H6X2 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T3 | Phosphorylation | Uniprot | |
| S75 | Phosphorylation | Uniprot | |
| Y119 | Phosphorylation | Uniprot | |
| Y132 | Phosphorylation | Uniprot | |
| Y133 | Phosphorylation | Uniprot | |
| Y139 | Phosphorylation | Uniprot | |
| N184 | N-Glycosylation | Uniprot | |
| K195 | Ubiquitination | Uniprot | |
| K270 | Ubiquitination | Uniprot | |
| S362 | Phosphorylation | Uniprot | |
| K374 | Ubiquitination | Uniprot | |
| T377 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| Y382 | Phosphorylation | Uniprot | |
| Y383 | Phosphorylation | Uniprot | |
| K401 | Ubiquitination | Uniprot | |
| K409 | Ubiquitination | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| Y425 | Phosphorylation | Uniprot | |
| K445 | Ubiquitination | Uniprot | |
| K451 | Ubiquitination | Uniprot | |
| K453 | Ubiquitination | Uniprot | |
| K488 | Ubiquitination | Uniprot | |
| Y501 | Phosphorylation | Uniprot | |
| T503 | Phosphorylation | Uniprot | |
| S563 | Phosphorylation | Uniprot |
研究背景
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells.
Cell membrane>Single-pass type I membrane protein. Cell projection>Lamellipodium membrane>Single-pass type I membrane protein. Cell projection>Filopodium membrane>Single-pass type I membrane protein.
Note: At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia.
Detected in umbilical vein endothelial cells (at protein level). Highly expressed in tumor endothelial cells.
Interacts with gelatin and type 1 collagen. Interacts with the actin cytoskeleton. Binds to the protective antigen (PA) of Bacillus anthracis. Binding does not occur in the presence of calcium.
Binding to PA occurs through the VWA domain.
Belongs to the ATR family.
研究領域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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