SCXA Antibody - #DF13293

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製品: SCXA Antibody
カタログ: DF13293
タンパク質の説明: Rabbit polyclonal antibody to SCXA
アプリケーション: WB IHC
Cited expt.: WB, IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse
分子量: 21kDa(Observed); 22kD(Calculated).
ユニプロット: Q7RTU7
RRID: AB_2846312

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#DF13293-BP

SCXA Peptide

1mg
関連ダウンロード
Antigen/Blocking Peptide MS Report
Antigen/Blocking Peptide HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(100%), Horse(100%)
クローナリティ:
Polyclonal
特異性:
SCXA Antibody detects endogenous levels of total SCXA.
RRID:
AB_2846312
引用形式: Affinity Biosciences Cat# DF13293, RRID:AB_2846312.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

Basic helix loop helix transcription factor scleraxis; Basic helix-loop-helix transcription factor scleraxis; bHLHa41; bHLHa48; Class A basic helix-loop-helix protein 41; Class A basic helix-loop-helix protein 48; scleraxis; scleraxis homolog A; SCX; SCX_HUMAN; SCXB;

免疫原

免疫原:

A synthesized peptide derived from human SCXA, corresponding to a region within the internal amino acids.

Uniprot:

Q7RTU7(SCX_HUMAN) >>Visit HPA database.

遺伝子(ID):
SCX(642658)
タンパク質配列:
MSFATLRPAPPGRYLYPEVSPLSEDEDRGSDSSGSDEKPCRVHAARCGLQGARRRAGGRRAGGGGPGGRPGREPRQRHTANARERDRTNSVNTAFTALRTLIPTEPADRKLSKIETLRLASSYISHLGNVLLAGEACGDGQPCHSGPAFFHAARAGSPPPPPPPPPARDGENTQPKQICTFCLSNQRKLSKDRDRKTAIRS

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
0
Dog
0
Xenopus
0
Zebrafish
0
Chicken
0
Rabbit
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages.

細胞の位置付け:

Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location

参考文献

1). Harnessing Mechanical Stress with Viscoelastic Biomaterials for Periodontal Ligament Regeneration. Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024 (PubMed: 38460171) [IF=15.1]
2). An all-silk-based functional system promotes tendon regeneration by regulating the cell fate of TSPCs in an inflammatory microenvironment. Acta Biomaterialia, 2025 [IF=9.6]
3). Small extracellular vesicles derived from tendon stem cells promote the healing of injured Achilles tendons by regulating miR-145-3p. Acta biomaterialia, 2023 (PubMed: 37806377) [IF=9.4]
4). Hypoxia Induces HIF-1α Activation in Tendon Stem Cells to Enhance Extracellular Vesicle-Mediated Tendon Repair. ACS applied materials & interfaces, 2025 (PubMed: 40675622) [IF=8.3]
5). Adipose-derived mesenchymal stromal cell-derived exosomes promote tendon healing by activating both SMAD1/5/9 and SMAD2/3. Stem Cell Research & Therapy, 2021 (PubMed: 34112236) [IF=7.5]

Application: IHC    Species: rat    Sample: tendon

Fig. 5 |ADSC-Exos improved the healing of tendon injury. a, h The H&E staining of tendon injury at week 2 and week 4. b–f, i–m The expression of TNMD, collagen I, SCXA, ALP, and Runx2 were detected by immunohistochemistry assay at week 2 (n = 6) and week 4 (n = 6).
6). The treatment of acute tendon injury with small extracellular vesicles originating from TNFAIP6- ADSCs subpopoulation both in vitro and in vivo. Stem cell research & therapy, 2025 (PubMed: 41469712) [IF=7.5]
7). Biological Augmentation Using Electrospun Constructs with Dual Growth Factor Release for Rotator Cuff Repair. ACS applied bio materials, 2025 (PubMed: 40012485) [IF=4.6]
8). Eugenol-Preconditioned Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Antioxidant Capacity of Tendon Stem Cells In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity, 2022 (PubMed: 35178155)

Application: WB    Species: Rat    Sample: TSCs

Figure 3 EUG-BMSC-EVs protected tenogenic differentiation of H2O2-treated TSCs. (a–e) Western blot was used to examine the expression of SCXA, TNMD, TNC, and COLI. (f–i) The expression of tenocyte-related genes, SCX, TNMD, TNC, and Col1a1. ∗P < 0.05, ∗∗P < 0.01, and ∗∗∗P < 0.001.

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Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
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