NNMT Antibody - #DF13190
| 製品: | NNMT Antibody |
| カタログ: | DF13190 |
| タンパク質の説明: | Rabbit polyclonal antibody to NNMT |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Dog |
| 分子量: | 30 kDa; 30kD(Calculated). |
| ユニプロット: | P40261 |
| RRID: | AB_2846150 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13190, RRID:AB_2846150.
折りたたみ／展開
EC 2.1.1.1; Nicotinamide N methyltransferase; Nicotinamide N-methyltransferase; NNMT; NNMT_HUMAN;
免疫原
Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.
- P40261 NNMT_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKHLLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQNLQELEKWLKKEPEAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLKCDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPGGFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQSYSSTMANNEGLFSLVARKLSRPL
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P40261 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| M1 | Acetylation | Uniprot | |
| S3 | Phosphorylation | Uniprot | |
| K8 | Acetylation | Uniprot | |
| K8 | Methylation | Uniprot | |
| K8 | Ubiquitination | Uniprot | |
| Y11 | Phosphorylation | Uniprot | |
| K23 | Ubiquitination | Uniprot | |
| Y24 | Phosphorylation | Uniprot | |
| Y25 | Phosphorylation | Uniprot | |
| K26 | Ubiquitination | Uniprot | |
| S35 | Phosphorylation | Uniprot | |
| K39 | Acetylation | Uniprot | |
| K39 | Ubiquitination | Uniprot | |
| K43 | Acetylation | Uniprot | |
| K43 | Ubiquitination | Uniprot | |
| K47 | Ubiquitination | Uniprot | |
| K96 | Ubiquitination | Uniprot | |
| K100 | Ubiquitination | Uniprot | |
| S108 | Phosphorylation | Uniprot | |
| Y113 | Phosphorylation | Uniprot | |
| K123 | Ubiquitination | Uniprot | |
| K136 | Ubiquitination | Uniprot | |
| Y203 | Phosphorylation | Uniprot | |
| Y204 | Phosphorylation | Uniprot | |
| K210 | Ubiquitination | Uniprot |
研究背景
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
Cytoplasm.
Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas.
Monomer.
Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family.
研究領域
· Metabolism > Metabolism of cofactors and vitamins > Nicotinate and nicotinamide metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
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