Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF13163, RRID:AB_2846123.
折りたたみ／展開
Helicase/primase complex protein; Myeloma overexpressed 2; Myeloma-overexpressed gene 2 protein; myeov2; MYOV2_HUMAN;
免疫原
A synthesized peptide derived from human MYEOV, corresponding to a region within the internal amino acids.
- Q8WXC6 CSN9_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDDDIQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation.
Negatively regulates neddylation of proteins, including ribosoaml protein RPL11.
Nucleus. Cytoplasm. Nucleus>Nucleoplasm.
Note: Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction.
Nucleus>Nucleoplasm.
Note: Excluded from the nucleolus.
The Phe/Asp-rich domain at the C-terminus is necessary for its incorporation into the CSN complex.
Amino acids 60-89 in isoform 2 are necessary for interaction with COPS5, CUL1, CUL3.
Belongs to the CSN9 family.
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