DDRGK1 Antibody - #DF12933
| 製品: | DDRGK1 Antibody |
| カタログ: | DF12933 |
| タンパク質の説明: | Rabbit polyclonal antibody to DDRGK1 |
| アプリケーション: | WB |
| 反応性: | Human, Mouse |
| 分子量: | 36 kDa; 36kD(Calculated). |
| ユニプロット: | Q96HY6 |
| RRID: | AB_2845894 |
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12933, RRID:AB_2845894.
折りたたみ／展開
1110001I20Rik; 2600009E05Rik; C20orf116; Chromosome 20 open reading frame 116; Dashurin; DDRGK domain containing 1; DDRGK domain containing protein 1; DDRGK domain-containing protein 1; DDRGK_HUMAN; Ddrgk1; dJ1187M17.3; MGC2592; OTTHUMP00000030088; RGD1309979; RP23-100C5.9; UFM1-binding and PCI domain-containing protein 1;
免疫原
A synthesized peptide derived from human DDRGK1, corresponding to a region within N-terminal amino acids.
Widely expressed (at protein level). In the brain, highest levels in medulla oblongata, followed by cerebral cortex, cerebellum and frontal lobe.
- Q96HY6 DDRGK_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MVAPVWYLVAAALLVGFILFLTRSRGRAASAGQEPLHNEELAGAGRVAQPGPLEPEEPRAGGRPRRRRDLGSRLQAQRRAQRVAWAEADENEEEAVILAQEEEGVEKPAETHLSGKIGAKKLRKLEEKQARKAQREAEEAEREERKRLESQREAEWKKEEERLRLEEEQKEEEERKAREEQAQREHEEYLKLKEAFVVEEEGVGETMTEEQSQSFLTEFINYIKQSKVVLLEDLASQVGLRTQDTINRIQDLLAEGTITGVIDDRGKFIYITPEELAAVANFIRQRGRVSIAELAQASNSLIAWGRESPAQAPA
研究背景
Protein which interacts with the E3 UFM1-protein ligase UFL1 and one of its substrates TRIP4 and is required for TRIP4 ufmylation. Through TRIP4 ufmylation may regulate nuclear receptors-mediated transcription. May play a role in NF-kappa-B-mediated transcription through regulation of the phosphorylation and the degradation of NFKBIA, the inhibitor of NF-kappa-B. May also play a role in the cellular response to endoplasmic reticulum stress (By similarity). Plays a role in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator.
Ubiquitinated. Ubiquitination probably triggers proteasomal degradation and is negatively regulated by UFL1, the enzyme involved in the ufmylation of DDRGK1.
Ufmylated. Conjugated to ubiquitin-like protein UFM1, probably at Lys-267 by UFL1.
Endoplasmic reticulum.
Widely expressed (at protein level). In the brain, highest levels in medulla oblongata, followed by cerebral cortex, cerebellum and frontal lobe.
Belongs to the DDRGK1 family.
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