製品: DTX2 Antibody
カタログ: DF12526
タンパク質の説明: Rabbit polyclonal antibody to DTX2
アプリケーション: WB
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Sheep, Rabbit, Dog
分子量: 67 kDa; 67kD(Calculated).
ユニプロット: Q86UW9
RRID: AB_2845488

類似製品を見る>>

   サイズ 価格 在庫状況
 100ul $280 在庫あり
 200ul $350 在庫あり

リードタイム: 当日配達

For pricing and ordering contact:
お問い合わせ先

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(100%), Horse(100%), Sheep(89%), Rabbit(100%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
DTX2 Antibody detects endogenous levels of total DTX2.
RRID:
AB_2845488
引用形式: Affinity Biosciences Cat# DF12526, RRID:AB_2845488.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

Deltex 2; deltex homolog 2 (Drosophila); deltex, Drosophila, homolog of, 2; Deltex2; DTX2; DTX2_HUMAN; hDTX2; Highly similar to hPMSR6 [H.sapiens]; KIAA1528; Probable E3 ubiquitin-protein ligase DTX2; Protein deltex 2; Protein deltex-2; RING finger protein 58; RNF58; Zinc ion binding protein;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
タンパク質配列:
MAMAPSPSLVQVYTSPAAVAVWEWQDGLGTWHPYSATVCSFIEQQFVQQKGQRFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQDTGTMRAVRRHLFPQHSAPGRGVVWEWLSDDGSWTAYEASVCDYLEQQVARGNQLVDLAPLGYNYTVNYTTHTQTNKTSSFCRSVRRQAGPPYPVTTIIAPPGHTGVACSCHQCLSGSRTGPVSGRYRHSMTNLPAYPVPQHPPHRTASVFGTHQAFAPYNKPSLSGARSAPRLNTTNAWGAAPPSLGSQPLYRSSLSHLGPQHLPPGSSTSGAVSASLPSGPSSSPGSVPATVPMQMPKPSRVQQALAGMTSVLMSAIGLPVCLSRAPQPTSPPASRLASKSHGSVKRLRKMSVKGATPKPEPEPEQVIKNYTEELKVPPDEDCIICMEKLSTASGYSDVTDSKAIGSLAVGHLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPQGKMEVLRFQMSLPGHEDCGTILIVYSIPHGIQGPEHPNPGKPFTARGFPRQCYLPDNAQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNITGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Dog
100
Rabbit
100
Sheep
89
Zebrafish
78
Chicken
78
Xenopus
75
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q86UW9 基板として

Site PTM Type Enzyme
Y75 Phosphorylation
T153 Phosphorylation
Y156 Phosphorylation
R213 Methylation
R215 Methylation
S217 Phosphorylation
R233 Methylation
S236 Phosphorylation
Y247 Phosphorylation
K249 Acetylation
K249 Ubiquitination
S251 Phosphorylation
S253 Phosphorylation
R256 Methylation
S257 Phosphorylation
Y280 Phosphorylation
R281 Methylation
S360 Phosphorylation
S364 Phosphorylation
S368 Phosphorylation
K369 Ubiquitination
S373 Phosphorylation
K379 Acetylation
K383 Acetylation
T386 Phosphorylation
K398 Ubiquitination
K473 Ubiquitination
K479 Ubiquitination
K553 Acetylation
K553 Ubiquitination
K557 Acetylation

研究背景

機能:

Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Probably acts both as a positive and negative regulator of Notch, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Functions as a ubiquitin ligase protein in vitro, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity.

細胞の位置付け:

Cytoplasm. Nucleus.
Note: Predominantly cytoplasmic. Partially nuclear.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
サブユニット構造:

Homodimer. May form a heterodimer with other members of the Deltex family. Interacts with NOTCH1.

タンパク質ファミリー:

The WWE domains are thought to mediate some protein-protein interaction, and are frequently found in ubiquitin ligases.

Belongs to the Deltex family.

研究領域

· Environmental Information Processing > Signal transduction > Notch signaling pathway.   (View pathway)

Restrictive clause

 

Affinity Biosciences tests all products strictly. Citations are provided as a resource for additional applications that have not been validated by Affinity Biosciences. Please choose the appropriate format for each application and consult Materials and Methods sections for additional details about the use of any product in these publications.

For Research Use Only.
Not for use in diagnostic or therapeutic procedures. Not for resale. Not for distribution without written consent. Affinity Biosciences will not be held responsible for patent infringement or other violations that may occur with the use of our products. Affinity Biosciences, Affinity Biosciences Logo and all other trademarks are the property of Affinity Biosciences LTD.