SEC63 Antibody - #DF12471
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12471, RRID:AB_2845276.
折りたたみ／展開
ERdj2; PRO2507; SEC 63; SEC63L; Translocation protein SEC63 homolog;
免疫原
- Q9UGP8 SEC63_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGQQFQYDDSGNTFFYFLTSFVGLIVIPATYYLWPRDQNAEQIRLKNIRKVYGRCMWYRLRLLKPQPNIIPTVKKIVLLAGWALFLFLAYKVSKTDREYQEYNPYEVLNLDPGATVAEIKKQYRLLSLKYHPDKGGDEVMFMRIAKAYAALTDEESRKNWEEFGNPDGPQATSFGIALPAWIVDQKNSILVLLVYGLAFMVILPVVVGSWWYRSIRYSGDQILIRTTQIYTYFVYKTRNMDMKRLIMVLAGASEFDPQYNKDATSRPTDNILIPQLIREIGSINLKKNEPPLTCPYSLKARVLLLSHLARMKIPETLEEDQQFMLKKCPALLQEMVNVICQLIVMARNREEREFRAPTLASLENCMKLSQMAVQGLQQFKSPLLQLPHIEEDNLRRVSNHKKYKIKTIQDLVSLKESDRHTLLHFLEDEKYEEVMAVLGSFPYVTMDIKSQVLDDEDSNNITVGSLVTVLVKLTRQTMAEVFEKEQSICAAEEQPAEDGQGETNKNRTKGGWQQKSKGPKKTAKSKKKKPLKKKPTPVLLPQSKQQKQKQANGVVGNEAAVKEDEEEVSDKGSDSEEEETNRDSQSEKDDGSDRDSDREQDEKQNKDDEAEWQELQQSIQRKERALLETKSKITHPVYSLYFPEEKQEWWWLYIADRKEQTLISMPYHVCTLKDTEEVELKFPAPGKPGNYQYTVFLRSDSYMGLDQIKPLKLEVHEAKPVPENHPQWDTAIEGDEDQEDSEGFEDSFEEEEEEEEDDD
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - Q9UGP8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| Y106 | Phosphorylation | Uniprot | |
| K121 | Ubiquitination | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| K135 | Ubiquitination | Uniprot | |
| K147 | Ubiquitination | Uniprot | |
| Y149 | Phosphorylation | Uniprot | |
| T153 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| T269 | Phosphorylation | Uniprot | |
| S283 | Phosphorylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K288 | Ubiquitination | Uniprot | |
| K300 | Ubiquitination | Uniprot | |
| S307 | Phosphorylation | Uniprot | |
| K313 | Ubiquitination | Uniprot | |
| K327 | Ubiquitination | Uniprot | |
| K381 | Ubiquitination | Uniprot | |
| K402 | Methylation | Uniprot | |
| K403 | Methylation | Uniprot | |
| K407 | Ubiquitination | Uniprot | |
| K416 | Ubiquitination | Uniprot | |
| S451 | Phosphorylation | Uniprot | |
| T475 | Phosphorylation | Uniprot | |
| T478 | Phosphorylation | Uniprot | |
| S488 | Phosphorylation | Uniprot | |
| K506 | Ubiquitination | Uniprot | |
| K510 | Ubiquitination | Uniprot | |
| K527 | Acetylation | Uniprot | |
| T537 | Phosphorylation | Uniprot | |
| S544 | Phosphorylation | Uniprot | |
| S570 | Phosphorylation | Uniprot | |
| S574 | Phosphorylation | Uniprot | |
| S576 | Phosphorylation | Uniprot | |
| S593 | Phosphorylation | Uniprot | |
| S597 | Phosphorylation | Uniprot | |
| K607 | Ubiquitination | Uniprot | |
| K623 | Ubiquitination | Uniprot | |
| K631 | Ubiquitination | Uniprot | |
| K633 | Ubiquitination | Uniprot | |
| Y642 | Phosphorylation | Uniprot | |
| K688 | Ubiquitination | Uniprot | |
| Y692 | Phosphorylation | Uniprot | |
| Y694 | Phosphorylation | Uniprot | |
| T695 | Phosphorylation | Uniprot | |
| K710 | Ubiquitination | Uniprot | |
| S742 | Phosphorylation | Uniprot | |
| S748 | Phosphorylation | Uniprot |
研究背景
Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity).
Endoplasmic reticulum membrane>Multi-pass membrane protein.
Widely expressed, with high levels in the liver.
The ER translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Protein export.
· Genetic Information Processing > Folding, sorting and degradation > Protein processing in endoplasmic reticulum. (View pathway)
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