製品: REEP6 Antibody
カタログ: DF12464
タンパク質の説明: Rabbit polyclonal antibody to REEP6
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
分子量: 22 kDa(Observed); 23kD(Calculated).
ユニプロット: Q96HR9
RRID: AB_2845269

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
クローナリティ:
Polyclonal
特異性:
REEP6 Antibody detects endogenous levels of total REEP6.
RRID:
AB_2845269
引用形式: Affinity Biosciences Cat# DF12464, RRID:AB_2845269.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

0610011M24Rik; C19orf32; Deleted in polyposis 1 like 1; Dp1l1; FLJ25383; OTTMUSP00000020650; OTTMUSP00000020651; OTTMUSP00000020652; OTTMUSP00000021713; OTTMUSP00000021714; Polyposis locus protein 1 like 1; Polyposis locus protein 1-like 1; Receptor accessory protein 6; Receptor expression enhancing protein 6; Receptor expression-enhancing protein 6; REEP6; REEP6_HUMAN; TB2 protein like 1; TB2L1;

免疫原

免疫原:

A synthesized peptide derived from human REEP6, corresponding to a region within C-terminal amino acids.

Uniprot:
遺伝子(ID):
発現特異性:
Q96HR9 REEP6_HUMAN:

Expressed in circumvallate papillae and testis (PubMed:16720576). Expressed in the retina. Isoform 1 is predominantly present in mature optic cups. Isoform 1 expression is confined to the cell body and inner segment of developing rod photoreceptor cells (PubMed:27889058).

タンパク質配列:
MDGLRQRVEHFLEQRNLVTEVLGALEAKTGVEKRYLAAGAVTLLSLYLLFGYGASLLCNLIGFVYPAYASIKAIESPSKDDDTVWLTYWVVYALFGLAEFFSDLLLSWFPFYYVGKCAFLLFCMAPRPWNGALMLYQRVVRPLFLRHHGAVDRIMNDLSGRALDAAAGITRNVLQVLARSRAGITPVAVAGPSTPLEADLKPSQTPQPKDK

研究背景

機能:

Required for correct function and survival of retinal photoreceptors. Required for retinal development (By similarity). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (By similarity). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (By similarity).

細胞の位置付け:

Endoplasmic reticulum membrane>Multi-pass membrane protein. Cytoplasmic vesicle>Clathrin-coated vesicle membrane>Multi-pass membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in circumvallate papillae and testis. Expressed in the retina. Isoform 1 is predominantly present in mature optic cups. Isoform 1 expression is confined to the cell body and inner segment of developing rod photoreceptor cells.

タンパク質ファミリー:

Belongs to the DP1 family.

Restrictive clause

 

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