PTP4A1/PRL1 Antibody - #DF12458

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製品: PTP4A1/PRL1 Antibody
カタログ: DF12458
タンパク質の説明: Rabbit polyclonal antibody to PTP4A1/PRL1
アプリケーション: WB IHC IF/ICC
Cited expt.: IHC
反応性: Human, Mouse, Rat
予測: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus
分子量: 22 kDa; 20kD(Calculated).
ユニプロット: Q93096
RRID: AB_2845263

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Zebrafish(89%), Bovine(100%), Horse(100%), Sheep(100%), Rabbit(100%), Dog(100%), Chicken(100%), Xenopus(100%)
クローナリティ:
Polyclonal
特異性:
PTP4A1/PRL1 Antibody detects endogenous levels of total PTP4A1/PRL1.
RRID:
AB_2845263
引用形式: Affinity Biosciences Cat# DF12458, RRID:AB_2845263.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

HH 72; HH72; Hypothetical protein DKFZp779M0721; Phosphatase of regenerating liver 1; PRL 1; PRL-1; PRL1; Protein tyrosine phosphatase PTPCAAX1; Protein tyrosine phosphatase type IVA 1; Protein tyrosine phosphatase type IVA member 1; Protein-tyrosine phosphatase 4a1; Protein-tyrosine phosphatase of regenerating liver 1; Protein-tyrosine phosphatase, type 4A, 1; PTP(CAAXI); Ptp4a1; PTPCAAX1; TP4A1_HUMAN;

免疫原

免疫原:

A synthesized peptide derived from human PTP4A1/PRL1, corresponding to a region within C-terminal amino acids.

Uniprot:

Q93096(TP4A1_HUMAN) >>Visit HPA database.

遺伝子(ID):
PTP4A1(7803)
発現特異性:
Q93096 TP4A1_HUMAN:

Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.

タンパク質配列:
MARMNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHRNNCCIQ

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Sheep
100
Dog
100
Xenopus
100
Chicken
100
Rabbit
100
Zebrafish
89
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis.

PTMs:

Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.

細胞の位置付け:

Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm>Cytoskeleton>Spindle.
Note: And mitotic spindle.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines.

タンパク質ファミリー:

Belongs to the protein-tyrosine phosphatase family.

参考文献

1). An organoid library of salivary gland tumors reveals subtype-specific characteristics and biomarkers. Journal of experimental & clinical cancer research : CR, 2022 (PubMed: 36527158) [IF=11.3]

Application: IHC    Species: human    Sample:

Fig. 8 Validation of the potential biomarkers in MEC. A RNA level of NEFL in SGTs by RT-PCR. * P 

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