製品: NSDHL Antibody
カタログ: DF12432
タンパク質の説明: Rabbit polyclonal antibody to NSDHL
アプリケーション: WB IHC
反応性: Human, Mouse, Rat
予測: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken
分子量: 42 kDa,40 kDa; 42kD(Calculated).
ユニプロット: Q15738
RRID: AB_2845237

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 100ul $280 在庫あり
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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Zebrafish(92%), Bovine(92%), Horse(83%), Sheep(92%), Rabbit(100%), Dog(100%), Chicken(92%)
クローナリティ:
Polyclonal
特異性:
NSDHL Antibody detects endogenous levels of total NSDHL.
RRID:
AB_2845237
引用形式: Affinity Biosciences Cat# DF12432, RRID:AB_2845237.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

decarboxylating; H105E3; H105e3 protein; NAD(P) dependent steroid dehydrogenase like; NSDHL; NSDHL_HUMAN; Protein H105e3; SDR31E1; Short chain dehydrogenase/reductase family 31E member 1; Sterol 4 alpha carboxylate 3 dehydrogenase decarboxylating; Sterol-4-alpha-carboxylate 3-dehydrogenase; XAP104;

免疫原

免疫原:
Uniprot:
遺伝子(ID):
発現特異性:
Q15738 NSDHL_HUMAN:

Brain, heart, liver, lung, kidney, skin and placenta.

タンパク質配列:
MEPAVSEPMRDQVARTHLTEDTPKVNADIEKVNQNQAKRCTVIGGSGFLGQHMVEQLLARGYAVNVFDIQQGFDNPQVRFFLGDLCSRQDLYPALKGVNTVFHCASPPPSSNNKELFYRVNYIGTKNVIETCKEAGVQKLILTSSASVIFEGVDIKNGTEDLPYAMKPIDYYTETKILQERAVLGANDPEKNFLTTAIRPHGIFGPRDPQLVPILIEAARNGKMKFVIGNGKNLVDFTFVENVVHGHILAAEQLSRDSTLGGKAFHITNDEPIPFWTFLSRILTGLNYEAPKYHIPYWVAYYLALLLSLLVMVISPVIQLQPTFTPMRVALAGTFHYYSCERAKKAMGYQPLVTMDDAMERTVQSFRHLRRVK

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Dog
100
Rabbit
100
Bovine
92
Sheep
92
Zebrafish
92
Chicken
92
Horse
83
Xenopus
75
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - Q15738 基板として

Site PTM Type Enzyme
M1 Acetylation
T19 Phosphorylation
T22 Phosphorylation
K24 Ubiquitination
K31 Ubiquitination
S87 Phosphorylation
K96 Ubiquitination
S106 Phosphorylation
K114 Ubiquitination
K126 Ubiquitination
K133 Ubiquitination
S147 Phosphorylation
Y164 Phosphorylation
K167 Ubiquitination
K176 Ubiquitination
K191 Ubiquitination
K232 Ubiquitination
K263 Ubiquitination
T284 Phosphorylation
Y288 Phosphorylation
K345 Ubiquitination
Y349 Phosphorylation
T354 Phosphorylation

研究背景

機能:

Involved in the sequential removal of two C-4 methyl groups in post-squalene cholesterol biosynthesis.

細胞の位置付け:

Endoplasmic reticulum membrane>Single-pass membrane protein. Lipid droplet.
Note: Trafficking through the Golgi is necessary for ER membrane localization.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Brain, heart, liver, lung, kidney, skin and placenta.

タンパク質ファミリー:

Belongs to the 3-beta-HSD family.

研究領域

· Metabolism > Lipid metabolism > Steroid biosynthesis.

· Metabolism > Global and overview maps > Metabolic pathways.

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For Research Use Only.
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