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製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12326, RRID:AB_2845131.
折りたたみ／展開
FLJ41801; Genethonin-1; Genethonin1; GENEX 3414; GENEX3414; GENX 3414; GENX3414; Starch binding domain 1; Starch binding domain containing protein 1; Starch-binding domain-containing protein 1; STBD 1; STBD1; STBD1_HUMAN;
免疫原
A synthesized peptide derived from human STBD1, corresponding to a region within N-terminal amino acids.
Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).
- O95210 STBD1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MGAVWSALLVGGGLAGALFVWLLRGGPGDTGKDGDAEQEKDAPLGGAAIPGGHQSGSSGLSPGPSGQELVTKPEHLQESNGHLISKTKDLGKLQAASWRLQNPSREVCDNSREHVPSGQFPDTEAPATSETSNSRSYSEVSRNESLESPMGEWGFQKGQEISAKAATCFAEKLPSSNLLKNRAKEEMSLSDLNSQDRVDHEEWEMVPRHSSWGDVGVGGSLKAPVLNLNQGMDNGRSTLVEARGQQVHGKMERVAVMPAGSQQVSVRFQVHYVTSTDVQFIAVTGDHECLGRWNTYIPLHYNKDGFWSHSIFLPADTVVEWKFVLVENGGVTRWEECSNRFLETGHEDKVVHAWWGIH
研究背景
Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.
Ubiquitinated, which leads to proteasomal degradation.
Preautophagosomal structure membrane>Single-pass type III membrane protein. Endoplasmic reticulum membrane>Single-pass type III membrane protein. Cell membrane>Sarcolemma>T-tubule.
Note: Also detected near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048).
Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).
The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.
The C-terminal CBM20 domain is required for the interaction with glycogen and glycogen-associated proteins.
参考文献
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