MDH1 Antibody - #DF12291
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12291, RRID:AB_2845096.
折りたたみ／展開
cytoplasmic; Cytosolic malate dehydrogenase; Diiodophenylpyruvate reductase; Malate dehydrogenase 1, NAD (soluble); Malate dehydrogenase; Malate dehydrogenase cytoplasmic; MDH s; mdh1; MDHA; MDHC_HUMAN; MDHs; MGC:1375; MOR2; Soluble malate dehydrogenase;
免疫原
- P40925 MDHC_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLKDVIATDKEDVAFKDLDVAILVGSMPRREGMERKDLLKANVKIFKSQGAALDKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKAQIALKLGVTANDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFVTTVQQRGAAVIKARKLSSAMSAAKAICDHVRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKESAFEFLSSA
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P40925 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S2 | Acetylation | Uniprot | |
| Y22 | Phosphorylation | Uniprot | |
| T71 | Phosphorylation | Uniprot | |
| K73 | Acetylation | Uniprot | |
| K73 | Ubiquitination | Uniprot | |
| S89 | Phosphorylation | Uniprot | |
| K103 | Acetylation | Uniprot | |
| K103 | Ubiquitination | Uniprot | |
| K107 | Acetylation | Uniprot | |
| K107 | Ubiquitination | Uniprot | |
| K110 | Methylation | Uniprot | |
| K110 | Ubiquitination | Uniprot | |
| S111 | Phosphorylation | Uniprot | |
| K118 | Acetylation | Uniprot | |
| K118 | Ubiquitination | Uniprot | |
| Y119 | Phosphorylation | Uniprot | |
| K121 | Acetylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| C137 | S-Nitrosylation | Uniprot | |
| K142 | Acetylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| K149 | Ubiquitination | Uniprot | |
| C154 | S-Nitrosylation | Uniprot | |
| K164 | Ubiquitination | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| T174 | Phosphorylation | Uniprot | |
| K179 | Ubiquitination | Uniprot | |
| S188 | Phosphorylation | Uniprot | |
| S189 | Phosphorylation | Uniprot | |
| T190 | Phosphorylation | Uniprot | |
| Y192 | Phosphorylation | Uniprot | |
| K199 | Ubiquitination | Uniprot | |
| K205 | Ubiquitination | Uniprot | |
| Y210 | Phosphorylation | Uniprot | |
| K214 | Acetylation | Uniprot | |
| K214 | Ubiquitination | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| K220 | Ubiquitination | Uniprot | |
| R230 | Methylation | Uniprot | |
| K236 | Ubiquitination | Uniprot | |
| K239 | Ubiquitination | Uniprot | |
| S241 | Phosphorylation | Uniprot | |
| S242 | Phosphorylation | Uniprot | |
| S245 | Phosphorylation | Uniprot | |
| T296 | Phosphorylation | Uniprot | |
| K298 | Acetylation | Uniprot | |
| K298 | Ubiquitination | Uniprot | |
| S309 | Phosphorylation | Uniprot | |
| K312 | Ubiquitination | Uniprot | |
| K318 | Ubiquitination | Uniprot | |
| T321 | Phosphorylation | Uniprot | |
| K324 | Ubiquitination | Uniprot | |
| S326 | Phosphorylation | Uniprot | |
| S332 | Phosphorylation | Uniprot | |
| S333 | Phosphorylation | Uniprot |
研究背景
ISGylated.
Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation.
Cytoplasm.
Homodimer.
Belongs to the LDH/MDH superfamily. MDH type 2 family.
研究領域
· Metabolism > Carbohydrate metabolism > Citrate cycle (TCA cycle).
· Metabolism > Amino acid metabolism > Cysteine and methionine metabolism.
· Metabolism > Carbohydrate metabolism > Pyruvate metabolism.
· Metabolism > Carbohydrate metabolism > Glyoxylate and dicarboxylate metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
· Organismal Systems > Excretory system > Proximal tubule bicarbonate reclamation.
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