Dermatopontin Antibody - #DF12196
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| 製品: | Dermatopontin Antibody |
| カタログ: | DF12196 |
| タンパク質の説明: | Rabbit polyclonal antibody to Dermatopontin |
| アプリケーション: | WB IHC |
| Cited expt.: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Rabbit, Dog |
| 分子量: | 22 kDa; 24kD(Calculated). |
| ユニプロット: | Q07507 |
| RRID: | AB_2845001 |
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12196, RRID:AB_2845001.
折りたたみ／展開
DERM_HUMAN; Dermatopontin; Dpt; TRAMP; Tyrosine rich acidic matrix protein; Tyrosine-rich acidic matrix protein;
免疫原
A synthesized peptide derived from human Dermatopontin, corresponding to a region within the internal amino acids.
Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
- Q07507 DERM_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MDLSLLWVLLPLVTMAWGQYGDYGYPYQQYHDYSDDGWVNLNRQGFSYQCPQGQVIVAVRSIFSKKEGSDRQWNYACMPTPQSLGEPTECWWEEINRAGMEWYQTCSNNGLVAGFQSRYFESVLDREWQFYCCRYSKRCPYSCWLTTEYPGHYGEEMDMISYNYDYYIRGATTTFSAVERDRQWKFIMCRMTEYDCEFANV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity).
Sulfated on tyrosine residue(s).
Secreted>Extracellular space>Extracellular matrix.
Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.
Belongs to the dermatopontin family.
参考文献
Application: WB Species: Human Sample: EC and AP tissues
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