CPLX1 Antibody - #DF12192
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| 製品: | CPLX1 Antibody |
| カタログ: | DF12192 |
| タンパク質の説明: | Rabbit polyclonal antibody to CPLX1 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Sheep, Dog, Chicken, Xenopus |
| 分子量: | 15-20 kDa; 15kD(Calculated). |
| ユニプロット: | O14810 |
| RRID: | AB_2844997 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12192, RRID:AB_2844997.
折りたたみ／展開
921-S; complexin 1; Complexin I; Complexin-1; CPLX1; CPLX1_HUMAN; CPX I; CPX-I; CPX1; Synaphin 2; Synaphin-2;
免疫原
Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
- O14810 CPLX1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREAVRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEVEEEDESILDTVIKYLPGPLQDMLKK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - O14810 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| K14 | Acetylation | Uniprot | |
| T95 | Phosphorylation | Uniprot | |
| S115 | Phosphorylation | Uniprot |
研究背景
Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior.
Cytoplasm>Cytosol. Perikaryon. Cell junction>Synapse>Presynapse.
Note: Enriched at synaptic-releasing sites in mature neurons.
Nervous system. In hippocampus and cerebellum, expressed mainly by inhibitory neurons. Overexpressed in substantia nigra from patients with Parkinson disease.
Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.
Belongs to the complexin/synaphin family.
研究領域
· Organismal Systems > Nervous system > Synaptic vesicle cycle.
参考文献
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