OXCT1 Antibody - #DF12082
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF12082, RRID:AB_2844887.
折りたたみ／展開
3 oxoacid CoA transferase 1; 3-oxoacid CoA-transferase 1; EC 2.8.3.5; OTTHUMP00000120012; OTTHUMP00000221550; OXCT; Oxct1; SCOT; Scot S; Scot-S; SCOT1_HUMAN; Somatic type succinyl CoA:3 oxoacid CoA transferase; Somatic-type succinyl-CoA:3-oxoacid CoA-transferase; Succinyl CoA:3 ketoacid CoA transferase; Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial; Succinyl CoA:3 oxoacid CoA transferase; Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial;
免疫原
Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
- P55809 SCOT1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAVKDIPDGATVLVGGFGLCGIPENLIDALLKTGVKGLTAVSNNAGVDNFGLGLLLRSKQIKRMVSSYVGENAEFERQYLSGELEVELTPQGTLAERIRAGGAGVPAFYTPTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFNGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAETTVVEVEEIVDIGAFAPEDIHIPQIYVHRLIKGEKYEKRIERLSIRKEGDGEAKSAKPGDDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNITVHLQSENGVLGLGPYPRQHEADADLINAGKETVTILPGASFFSSDESFAMIRGGHVDLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSAKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKAVFDVDKKKGLTLIELWEGLTVDDVQKSTGCDFAVSPKLMPMQQIAN
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P55809 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T86 | Phosphorylation | Uniprot | |
| S114 | Phosphorylation | Uniprot | |
| Y115 | Phosphorylation | Uniprot | |
| Y126 | Phosphorylation | Uniprot | |
| R146 | Methylation | Uniprot | |
| T157 | Phosphorylation | Uniprot | |
| T163 | Phosphorylation | Uniprot | |
| S170 | Phosphorylation | Uniprot | |
| K173 | Ubiquitination | Uniprot | |
| Y174 | Phosphorylation | Uniprot | |
| K176 | Acetylation | Uniprot | |
| K176 | Ubiquitination | Uniprot | |
| K185 | Acetylation | Uniprot | |
| K185 | Ubiquitination | Uniprot | |
| K225 | Acetylation | Uniprot | |
| S294 | Phosphorylation | Uniprot | |
| S381 | Phosphorylation | Uniprot | |
| K406 | Acetylation | Uniprot | |
| K418 | Acetylation | Uniprot | |
| K421 | Acetylation | Uniprot | |
| K421 | Ubiquitination | Uniprot | |
| S431 | Phosphorylation | Uniprot | |
| S432 | Phosphorylation | Uniprot | |
| T435 | Phosphorylation | Uniprot | |
| K446 | Ubiquitination | Uniprot | |
| K455 | Acetylation | Uniprot | |
| K463 | Ubiquitination | Uniprot | |
| K473 | Acetylation | Uniprot | |
| K473 | Ubiquitination | Uniprot | |
| K480 | Acetylation | Uniprot | |
| K480 | Ubiquitination | Uniprot | |
| K481 | Acetylation | Uniprot | |
| K482 | Acetylation | Uniprot | |
| S509 | Phosphorylation | Uniprot |
研究背景
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
Mitochondrion matrix.
Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
Homodimer.
Belongs to the 3-oxoacid CoA-transferase family.
研究領域
· Metabolism > Lipid metabolism > Synthesis and degradation of ketone bodies.
· Metabolism > Amino acid metabolism > Valine, leucine and isoleucine degradation.
· Metabolism > Carbohydrate metabolism > Butanoate metabolism.
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