製品: CISD1 Antibody
カタログ: DF12038
タンパク質の説明: Rabbit polyclonal antibody to CISD1
アプリケーション: WB IHC
反応性: Human, Mouse, Rat, Zebrafish
予測: Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Chicken, Xenopus
分子量: 14-17 kDa(Observed); 12kD(Calculated).
ユニプロット: Q9NZ45
RRID: AB_2844843

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 100ul $280 在庫あり
 200ul $350 在庫あり

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製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat,Zebrafish
予測:
Pig(88%), Bovine(88%), Horse(88%), Sheep(88%), Rabbit(100%), Chicken(88%), Xenopus(88%)
クローナリティ:
Polyclonal
特異性:
CISD1 Antibody detects endogenous levels of total CISD1.
RRID:
AB_2844843
引用形式: Affinity Biosciences Cat# DF12038, RRID:AB_2844843.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ/展開

AU043990; AW743335; C10orf70; CDGSH iron sulfur domain 1; CDGSH iron-sulfur domain-containing protein 1; CISD 1; CISD1; CISD1_HUMAN; D10Ertd214e; MDS029; MGC14684; MitoNEET; RGD1309529; ZCD1; Zinc finger CDGSH type domain 1;

免疫原

免疫原:

A synthesized peptide derived from human CISD1, corresponding to a region within the internal amino acids.

Uniprot:
遺伝子(ID):
発現特異性:
Q9NZ45 CISD1_HUMAN:

Expression is reduced in cells derived from cystic fibrosis patients.

タンパク質配列:
MSLTSSSSVRVEWIAAVTIAAGTAAIGYLAYKRFYVKDHRNKAMINLHIQKDNPKIVHAFDMEDLGDKAVYCRCWRSKKFPFCDGAHTKHNEETGDNVGPLIIKKKET

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Rabbit
100
Zebrafish
100
Pig
88
Horse
88
Bovine
88
Sheep
88
Xenopus
88
Chicken
88
Dog
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions.

PTMs:

Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.

細胞の位置付け:

Mitochondrion outer membrane>Single-pass type III membrane protein.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Expression is reduced in cells derived from cystic fibrosis patients.

タンパク質ファミリー:

Belongs to the CISD protein family.

Restrictive clause

 

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For Research Use Only.
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