SRX1 Antibody - #DF12028

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製品: SRX1 Antibody
カタログ: DF12028
タンパク質の説明: Rabbit polyclonal antibody to SRX1
アプリケーション: WB IHC
Cited expt.: WB, IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Sheep, Rabbit, Dog
分子量: 14 kDa; 14kD(Calculated).
ユニプロット: Q9BYN0
RRID: AB_2844833

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse,Rat
予測:
Pig(100%), Bovine(92%), Sheep(92%), Rabbit(100%), Dog(100%)
クローナリティ:
Polyclonal
特異性:
SRX1 Antibody detects endogenous levels of total SRX1.
RRID:
AB_2844833
引用形式: Affinity Biosciences Cat# DF12028, RRID:AB_2844833.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

C20orf1392; Chromosome 20 open reading frame 139; dJ850E9.2; Npn3; Npn31; SRX1; SRXN 1; Sulfiredoxin 1; Sulfiredoxin 1 homolog (S. cerevisiae); Sulfiredoxin 1 homolog; YKL086W;

免疫原

免疫原:

A synthesized peptide derived from human SRX1, corresponding to a region within the internal amino acids.

Uniprot:

Q9BYN0(SRXN1_HUMAN) >>Visit HPA database.

遺伝子(ID):
SRXN1(140809)
発現特異性:
Q9BYN0 SRXN1_HUMAN:

Widely expressed with highest levels in kidney, lung, spleen and thymus.

タンパク質配列:
MGLRAGGTLGRAGAGRGAPEGPGPSGGAQGGSIHSGRIAAVHNVPLSVLIRPLPSVLDPAKVQSLVDTIREDPDSVPPIDVLWIKGAQGGDYFYSFGGCHRYAAYQQLQRETIPAKLVQSTLSDLRVYLGASTPDLQ

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Dog
100
Rabbit
100
Bovine
92
Sheep
92
Horse
0
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase.

細胞の位置付け:

Cytoplasm.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Widely expressed with highest levels in kidney, lung, spleen and thymus.

タンパク質ファミリー:

Belongs to the sulfiredoxin family.

参考文献

1). Proteotranscriptomics Analysis Reveals the Key Pathways and Genes Involved in Apigenin's Anti-Liver Fibrosis Effects. Journal of proteome research, 2025 (PubMed: 40397522) [IF=3.8]
2). Ferroptosis-related gene expression in the pathogenesis of preeclampsia. Frontiers in Genetics, 2022 (PubMed: 36061193) [IF=3.7]

Application: WB    Species: Human    Sample:

FIGURE 6 Diagnostic accuracy analysis and experimental verification of six hub genes. (A–F) ROC curves were plotted to examine the diagnostic potential and discriminatory accuracy of NQO1 (A), SRXN1 (B), CDO1 (C), EGFR (D), FBXW7 (E), and JUN. (F–I) Western blot analysis of NQO1 and SRXN1 protein expression (G), and gray-scale analysis of Western blot analysis results (H–J). Representative images of immunohistochemical staining for NQO1 and SRXN1 in human placenta from normal pregnancy and preeclampsia. (K,L) Statistical analysis of immunohistochemistry results in non-PE placenta tissues (n = 15) and PE placenta tissues (n = 15). IHC means immunohistochemistry. *p < 0.05; **p < 0.01; ***p < 0.001. Scale bars = 50 μm in (J).

Application: IHC    Species: Human    Sample:

FIGURE 6 Diagnostic accuracy analysis and experimental verification of six hub genes. (A–F) ROC curves were plotted to examine the diagnostic potential and discriminatory accuracy of NQO1 (A), SRXN1 (B), CDO1 (C), EGFR (D), FBXW7 (E), and JUN. (F–I) Western blot analysis of NQO1 and SRXN1 protein expression (G), and gray-scale analysis of Western blot analysis results (H–J). Representative images of immunohistochemical staining for NQO1 and SRXN1 in human placenta from normal pregnancy and preeclampsia. (K,L) Statistical analysis of immunohistochemistry results in non-PE placenta tissues (n = 15) and PE placenta tissues (n = 15). IHC means immunohistochemistry. *p < 0.05; **p < 0.01; ***p < 0.001. Scale bars = 50 μm in (J).

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