Phospho-PSMC5 (Ser120) Antibody - #AF4452
| 製品: | Phospho-PSMC5 (Ser120) Antibody |
| カタログ: | AF4452 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-PSMC5 (Ser120) |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Zebrafish, Bovine, Horse, Sheep, Rabbit, Dog, Chicken, Xenopus |
| 分子量: | 46kDa; 46kD(Calculated). |
| ユニプロット: | P62195 |
| RRID: | AB_2844511 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF4452, RRID:AB_2844511.
折りたたみ／展開
26S protease regulatory subunit 8; 26S proteasome AAA-ATPase subunit RPT6; Cim3; MSUG1 protein; p45; p45/SUG; Proteasome 26S ATPase subunit 5; Proteasome 26S subunit ATPase 5; Proteasome prosome macropain 26S subunit ATPase 5; Proteasome subunit p45; PRS8_HUMAN; PSMC5; Rpt6; S8; SUG1; Tat binding protein homolog 10; TBP10; Thyroid hormone receptor interacting protein 1; Thyroid hormone receptor-interacting protein 1; Thyroid receptor interactor 1; TRIP1; TRIP1(SUG1);
免疫原
- P62195 PRS8_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRRLQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P62195 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| A2 | Acetylation | Uniprot | |
| K15 | Ubiquitination | Uniprot | |
| R21 | Methylation | Uniprot | |
| Y24 | Phosphorylation | Uniprot | |
| S26 | Phosphorylation | Uniprot | |
| K27 | Ubiquitination | Uniprot | |
| K38 | Ubiquitination | Uniprot | |
| K55 | Ubiquitination | Uniprot | |
| Y72 | Phosphorylation | Uniprot | |
| K88 | Ubiquitination | Uniprot | |
| K94 | Acetylation | Uniprot | |
| K94 | Ubiquitination | Uniprot | |
| K101 | Ubiquitination | Uniprot | |
| T109 | Phosphorylation | Uniprot | |
| C112 | S-Nitrosylation | Uniprot | |
| S120 | Phosphorylation | P17612 (PRKACA) | Uniprot |
| Y121 | Phosphorylation | Uniprot | |
| K125 | Ubiquitination | Uniprot | |
| K130 | Ubiquitination | Uniprot | |
| S136 | Phosphorylation | Uniprot | |
| K142 | Ubiquitination | Uniprot | |
| T147 | Phosphorylation | Uniprot | |
| Y148 | Phosphorylation | Uniprot | |
| K156 | Ubiquitination | Uniprot | |
| K162 | Ubiquitination | Uniprot | |
| K170 | Ubiquitination | Uniprot | |
| K184 | Ubiquitination | Uniprot | |
| Y189 | Phosphorylation | Uniprot | |
| K196 | Ubiquitination | Uniprot | |
| T197 | Phosphorylation | Uniprot | |
| S217 | Phosphorylation | Uniprot | |
| K222 | Acetylation | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| S244 | Phosphorylation | Uniprot | |
| S256 | Phosphorylation | Uniprot | |
| S257 | Phosphorylation | Uniprot | |
| S263 | Phosphorylation | Uniprot | |
| K287 | Ubiquitination | Uniprot | |
| K290 | Ubiquitination | Uniprot | |
| S303 | Phosphorylation | Uniprot | |
| K314 | Ubiquitination | Uniprot | |
| K330 | Ubiquitination | Uniprot | |
| K346 | Ubiquitination | Uniprot | |
| K360 | Ubiquitination | Uniprot | |
| T364 | Phosphorylation | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K397 | Ubiquitination | Uniprot | |
| K402 | Ubiquitination | Uniprot | |
| K403 | Ubiquitination | Uniprot |
研究背景
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC5 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.
Cytoplasm. Nucleus.
Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits, a base containing 6 ATPases including PSMC5 and few additional components. Component of a complex with USP49 and RUVBL1. Interacts with PRPF19. Interacts with TRIM5. Interacts with NDC80. Interacts with PAAF1. Interacts, in vitro, with the thyroid hormone receptor (in a thyroid hormone T3-dependent manner) and with retinoid X receptor (RXR) (By similarity). Interacts with ERCC6.
Belongs to the AAA ATPase family.
研究領域
· Genetic Information Processing > Folding, sorting and degradation > Proteasome.
· Human Diseases > Infectious diseases: Viral > Epstein-Barr virus infection.
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