Coagulation Factor III Antibody - #AF7723

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製品: Coagulation Factor III Antibody
カタログ: AF7723
タンパク質の説明: Rabbit polyclonal antibody to Coagulation Factor III
アプリケーション: WB IF/ICC
反応性: Human, Mouse
予測: Pig, Bovine, Sheep
分子量: 33kDa, 50 kDa; 33kD(Calculated).
ユニプロット: P13726
RRID: AB_2844087

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MS Report
HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:500-1:2000, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human,Mouse
予測:
Pig(88%), Bovine(86%), Sheep(86%)
クローナリティ:
Polyclonal
特異性:
Coagulation Factor III Antibody detects endogenous levels of total Coagulation Factor III.
RRID:
AB_2844087
引用形式: Affinity Biosciences Cat# AF7723, RRID:AB_2844087.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin (Thermo Fisher Scientific).
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

CD142; CD142 antigen; Coagulation factor III (thromboplastin tissue factor); Coagulation factor III; F3; FLJ17960; TF; TF_HUMAN; TFA; Thromboplastin; Tissue factor;

免疫原

免疫原:
Uniprot:

P13726(TF_HUMAN) >>Visit HPA database.

遺伝子(ID):
F3(2152)
発現特異性:
P13726 TF_HUMAN:

Lung, placenta and pancreas.

タンパク質配列:
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
88
Bovine
86
Sheep
86
Rabbit
75
Dog
71
Horse
67
Xenopus
0
Zebrafish
0
Chicken
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

PTMs - P13726 基板として

Site PTM Type Enzyme
K100 Ubiquitination
S120 Phosphorylation
S285 Phosphorylation Q16539 (MAPK14) , P17252 (PRKCA)
K287 Methylation
K287 Ubiquitination
S290 Phosphorylation P17252 (PRKCA) , Q16539 (MAPK14)
S295 Phosphorylation

研究背景

機能:

Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.

細胞の位置付け:

Membrane>Single-pass type I membrane protein.

Secreted.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Lung, placenta and pancreas.

サブユニット構造:

Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII.

タンパク質ファミリー:

Belongs to the tissue factor family.

研究領域

· Organismal Systems > Immune system > Complement and coagulation cascades.   (View pathway)

参考文献

1). Colchicine inhibits the prothrombotic effects of oxLDL in human endothelial cells. VASCULAR PHARMACOLOGY (PubMed: 33232770) [IF=4.0]

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