Phospho-FBP1 (Tyr265) Antibody - #AF7060
| 製品: | Phospho-FBP1 (Tyr265) Antibody |
| カタログ: | AF7060 |
| タンパク質の説明: | Rabbit polyclonal antibody to Phospho-FBP1 (Tyr265) |
| アプリケーション: | WB |
| 反応性: | Human, Mouse, Rat |
| 予測: | Pig, Bovine, Horse, Rabbit, Dog, Chicken |
| 分子量: | 37kDa; 37kD(Calculated). |
| ユニプロット: | P09467 |
| RRID: | AB_2843500 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# AF7060, RRID:AB_2843500.
折りたたみ／展開
6-bisphosphatase 1; 6-bisphosphate 1-phosphohydrolase 1; D fructose 1 6 bisphosphate 1 phosphohydrolase 1; D-fructose-1; EC 3.1.3.11; F16P1_HUMAN; FBP; FBP 1; FBP1; FBPase 1; Fructose 1 6 bisphosphatase 1; Fructose bisphosphatase 1; Fructose-1; Growth inhibiting protein 17; Liver fructose bisphosphatase;
免疫原
- P09467 F16P1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P09467 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| T28 | Phosphorylation | Uniprot | |
| Y58 | Phosphorylation | Uniprot | |
| S63 | Phosphorylation | Uniprot | |
| K72 | Acetylation | Uniprot | |
| S88 | Phosphorylation | Uniprot | |
| S144 | Phosphorylation | Uniprot | |
| Y216 | Phosphorylation | Uniprot | |
| Y227 | Phosphorylation | Uniprot | |
| K232 | Acetylation | Uniprot | |
| Y241 | Phosphorylation | Uniprot | |
| Y245 | Phosphorylation | Uniprot | |
| T256 | Phosphorylation | Uniprot | |
| Y259 | Phosphorylation | Uniprot | |
| Y265 | Phosphorylation | Uniprot | |
| K269 | Acetylation | Uniprot | |
| S271 | Phosphorylation | Uniprot | |
| T297 | Phosphorylation | Uniprot | |
| T298 | Phosphorylation | Uniprot | |
| S321 | Phosphorylation | Uniprot | |
| K330 | Acetylation | Uniprot |
研究背景
Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
Expressed in pancreatic islets.
Homotetramer.
Belongs to the FBPase class 1 family.
研究領域
· Environmental Information Processing > Signal transduction > AMPK signaling pathway. (View pathway)
· Metabolism > Carbohydrate metabolism > Glycolysis / Gluconeogenesis.
· Metabolism > Carbohydrate metabolism > Pentose phosphate pathway.
· Metabolism > Carbohydrate metabolism > Fructose and mannose metabolism.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Carbon metabolism.
· Organismal Systems > Endocrine system > Insulin signaling pathway. (View pathway)
· Organismal Systems > Endocrine system > Glucagon signaling pathway.
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