SH3BGRL3 Antibody - #DF9905

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製品: SH3BGRL3 Antibody
カタログ: DF9905
タンパク質の説明: Rabbit polyclonal antibody to SH3BGRL3
アプリケーション: WB IHC
Cited expt.: IHC
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Horse, Rabbit, Dog, Chicken
分子量: 10 kDa(Observed); 10kD(Calculated).
ユニプロット: Q9H299
RRID: AB_2843099

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#DF9905-BP

SH3BGRL3 Peptide

1mg
関連ダウンロード
Antigen/Blocking Peptide MS Report
Antigen/Blocking Peptide HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
WB 1:1000-3000, IHC 1:50-1:200
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
予測:
Pig(100%), Bovine(%), Horse(%), Rabbit(%), Dog(%), Chicken(%)
クローナリティ:
Polyclonal
特異性:
SH3BGRL3 Antibody detects endogenous levels of total SH3BGRL3.
RRID:
AB_2843099
引用形式: Affinity Biosciences Cat# DF9905, RRID:AB_2843099.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

epididymis secretory protein Li 297; HEL-S-297; SH3 domain binding glutamic acid rich protein like 3; SH3 domain-binding glutamic acid-rich-like protein 3; SH3 domain-binding protein 1; Sh3bgrl3; SH3BGRL3 like protein; SH3BP-1; SH3L3_HUMAN; TIP B1; TIP-B1; TNF inhibitory protein;

免疫原

免疫原:

A synthesized peptide derived from human SH3BGRL3, corresponding to a region within the internal amino acids.

Uniprot:

Q9H299(SH3L3_HUMAN) >>Visit HPA database.

遺伝子(ID):
SH3BGRL3(83442)
発現特異性:
Q9H299 SH3L3_HUMAN:

Ubiquitous.

タンパク質配列:
MSGLRVYSTSVTGSREIKSQQSEVTRILDGKRIQYQLVDISQDNALRDEMRALAGNPKATPPQIVNGDQYCGDYELFVEAVEQNTLQEFLKLA

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Horse
100
Bovine
100
Dog
100
Rabbit
100
Chicken
92
Zebrafish
69
Xenopus
62
Sheep
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Could act as a modulator of glutaredoxin biological activity.

細胞の位置付け:

Cytoplasm. Nucleus.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
組織特異性:

Ubiquitous.

タンパク質ファミリー:

Belongs to the SH3BGR family.

参考文献

1). Construction and validation of renal cell carcinoma tumor cell differentiation-related prognostic classification (RCC-TCDC): an integrated bioinformatic analysis and clinical study. Annals of medicine, 2025 (PubMed: 40248945) [IF=4.9]

Application: IHC    Species: human    Sample:

Figure 5. IHC staining and scoring for classifying patients in Xinhua cohort based on RCC-TCDC. (A) Flowchart showing the inclusion of patients with kidney neoplasms in our clinical center for successive validation processes of RCC-TCDC. (B) Boxplots showing differential expression patterns of the five selected markers for each RCC-TCDC subtype based on gene expression profiles from TCGA-KIRC. Specifically, S100A11 and SH3BGRL3 were markers for RCC-LD, TSPAN7 was a marker for RCC-MD, and AQP1 and NPR3 were markers for RCC-HD. (C) IHC slides showing the differential staining results of S100A11, SH3BGRL3, TSPAN7, AQP1, and NPR3 in each RCC-TCDC subtype. Abbreviations: IHC, immunohistochemical; RCC-TCDC, renal cell carcinoma-tumor cell differentiation-related prognostic classification; TCDGs, tumor cell differentiation-related prognostic genes; RCC-LD, renal cell carcinoma-low differentiation; RCC-MD, renal cell carcinoma-moderate differentiation; RCC-HD, renal cell carcinoma-low differentiation.
2). Differential expression of serum proteins before 20 weeks gestation in women with hypertensive disorders of pregnancy: A potential role for SH3BGRL3. Placenta, 2021 (PubMed: 33217630) [IF=3.0]

Application: IF/ICC    Species: Human    Sample: placenta tissue

Fig. 2. Median serum levels of (A) endoglin and (B) SH3BGRL3 before 20 weeks gestation in women who experienced an uncomplicated pregnancy and women who later developed HDP by quantitative proteomics (***P < 0.001). C: Confocal microscope images of anti-SH3BGRL3 in placenta tissue. The immunoreactivity of SH3BGRL3 (red) was higher in HDP patients compared to normal pregnancies. Cell nuclei were stained with DAPI (blue). Original magnification 40 × .

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