SERP1 Antibody - #DF9873

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製品: SERP1 Antibody
カタログ: DF9873
タンパク質の説明: Rabbit polyclonal antibody to SERP1
アプリケーション: IHC IF/ICC
Cited expt.:
反応性: Human, Mouse, Rat
予測: Pig, Bovine, Rabbit, Chicken
分子量: 7 kDa(Observed); 7kD(Calculated).
ユニプロット: Q9Y6X1
RRID: AB_2843067

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#DF9873-BP

SERP1 Peptide

1mg
関連ダウンロード
Antigen/Blocking Peptide MS Report
Antigen/Blocking Peptide HPLC Report
MSDS
説明書
COA
プロトコル
WB Handbook
IHC Protocol
IF/ICC Protocol

製品説明

ソース:
Rabbit
アプリケーション:
IHC 1:50-1:200, IF/ICC 1:100-1:500
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:

WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.

反応性:
Human, Mouse, Rat
予測:
Pig(100%), Bovine(%), Rabbit(%), Chicken(%)
クローナリティ:
Polyclonal
特異性:
SERP1 Antibody detects endogenous levels of total SERP1.
RRID:
AB_2843067
引用形式: Affinity Biosciences Cat# DF9873, RRID:AB_2843067.
コンジュゲート:
Unconjugated.
精製:
The antiserum was purified by peptide affinity chromatography using SulfoLink™ Coupling Resin.
保存:
Rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Store at -20 °C. Stable for 12 months from date of receipt.
別名:

折りたたみ／展開

D3Ucla1; Ramp4; Ribosome associated membrane protein 4; Ribosome attached membrane protein 4; Ribosome-attached membrane protein 4; Serp1; SERP1_HUMAN; Stress associated endoplasmic reticulum protein 1; Stress-associated endoplasmic reticulum protein 1;

免疫原

免疫原:

A synthesized peptide derived from human SERP1, corresponding to a region within the internal amino acids.

Uniprot:

Q9Y6X1(SERP1_HUMAN) >>Visit HPA database.

遺伝子(ID):
SERP1(27230)
タンパク質配列:
MVAKQRIRMANEKHSKNITQRGNVAKTSRNAPEEKASVGPWLLALFIFVVCGSAIFQIIQSIRMGM

種類予測

種類予測:

Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.

Species
Results
Score
Pig
100
Bovine
100
Rabbit
100
Chicken
92
Xenopus
67
Zebrafish
67
Horse
0
Sheep
0
Dog
0
Model Confidence:
High(score>80) Medium(80>score>50) Low(score<50) No confidence

研究背景

機能:

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).

細胞の位置付け:

Membrane>Single-pass type IV membrane protein. Endoplasmic reticulum membrane>Single-pass membrane protein>Cytoplasmic side.

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionSubcellular location
タンパク質ファミリー:

Belongs to the RAMP4 family.

参考文献

1). SERP1 reduces inchoate acute hepatic injury through regulation of endoplasmic reticulum stress via the GSK3β/β‑catenin/TCF/LEF signaling pathway. Molecular Medicine Reports, 2022 (PubMed: 35419615) [IF=3.4]

Application: WB    Species: Mouse    Sample:

Figure 1. - Establishment of an inchoate acute hepatic injury model and detection of ERS-related proteins. (A) Pathological changes of tissues of mice in the model group detected by H&E staining. (B) Levels of alanine aminotransferase and aspartate aminotransferase in the serum. (C) ERS-related protein expression detected by western blotting. SERP1 expression in acute hepatic injury tissues detected by (D) immunohistochemistry and (E) western blotting. (F) SERP1 expression in acute hepatic injury cells detected by western blotting and reverse transcription-quantitative PCR. *P

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