| 製品: | RAB43 Antibody |
| カタログ: | DF9833 |
| タンパク質の説明: | Rabbit polyclonal antibody to RAB43 |
| アプリケーション: | WB IHC |
| 反応性: | Human, Mouse |
| 予測: | Pig, Horse |
| 分子量: | 23 kDa(Observed); 23kD(Calculated). |
| ユニプロット: | Q86YS6 |
| RRID: | AB_2843027 |
Control Products
製品説明
*The optimal dilutions should be determined by the end user. For optimal experimental results, antibody reuse is not recommended.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9833, RRID:AB_2843027.
折りたたみ／展開
RAB41; RAB43; RAB43_HUMAN; Ras related protein Rab 41; Ras related protein Rab 43; Ras-related protein Rab-41; Ras-related protein Rab-43;
免疫原
A synthesized peptide derived from human RAB43, corresponding to a region within the internal amino acids.
Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.
- Q86YS6 RAB43_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MAGPGPGPGDPDEQYDFLFKLVLVGDASVGKTCVVQRFKTGAFSERQGSTIGVDFTMKTLEIQGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDITKRSSFLSVPHWIEDVRKYAGSNIVQLLIGNKSDLSELREVSLAEAQSLAEHYDILCAIETSAKDSSNVEEAFLRVATELIMRHGGPLFSEKSPDHIQLNSKDIGEGWGCGC
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
研究背景
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. The low intrinsic GTPase activity of RAB43 is activated by USP6NL. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for the structural integrity of the Golgi complex. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis.
Cytoplasmic vesicle>Phagosome. Cytoplasmic vesicle>Phagosome membrane>Lipid-anchor>Cytoplasmic side. Golgi apparatus. Golgi apparatus>trans-Golgi network membrane>Lipid-anchor. Golgi apparatus>trans-Golgi network.
Note: Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211).
Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.
Belongs to the small GTPase superfamily. Rab family.
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