ACSL1 Antibody - #DF9605
(1)
(6)
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9605, RRID:AB_2842801.
折りたたみ／展開
ACS 1; ACS1; ACSL 1; ACSL1; ACSL1_HUMAN; Acyl CoA synthetase 1; Acyl CoA synthetase long chain family member 1; Acyl-CoA synthetase 1; FACL 1; FACL 2; FACL1; FACL2; Fatty acid Coenzyme A ligase long chain 1; Fatty acid Coenzyme A ligase long chain 2; LACS 1; LACS 2; LACS; LACS1; LACS2; Lignoceroyl CoA synthase; Long chain acyl CoA synthetase 1; Long chain acyl CoA synthetase 2; Long chain fatty acid CoA ligase 1; Long chain fatty acid CoA ligase 2; Long chain fatty acid coenzyme A ligase 1; Long-chain acyl-CoA synthetase 1; Long-chain acyl-CoA synthetase 2; Long-chain fatty acid-CoA ligase 2; Long-chain-fatty-acid--CoA ligase 1; Palmitoyl CoA ligase 1; Palmitoyl CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2; Paltimoyl CoA ligase 1;
免疫原
Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.
- P33121 ACSL1_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
種類予測
Score>80(red) has high confidence and is suggested to be used for WB detection. *The prediction model is mainly based on the alignment of immunogen sequences, the results are for reference only, not as the basis of quality assurance.
High(score>80) Medium(80>score>50) Low(score<50) No confidence
PTMs - P33121 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S103 | Phosphorylation | Uniprot | |
| S122 | Phosphorylation | Uniprot | |
| Y188 | Phosphorylation | Uniprot | |
| K216 | Ubiquitination | Uniprot | |
| K222 | Ubiquitination | Uniprot | |
| S232 | Phosphorylation | Uniprot | |
| K356 | Ubiquitination | Uniprot | |
| K386 | Acetylation | Uniprot | |
| S394 | Phosphorylation | Uniprot | |
| K395 | Acetylation | Uniprot | |
| K395 | Ubiquitination | Uniprot | |
| S410 | Phosphorylation | Uniprot | |
| K419 | Ubiquitination | Uniprot | |
| S439 | Phosphorylation | Uniprot | |
| K532 | Ubiquitination | Uniprot | |
| Y567 | Phosphorylation | Uniprot | |
| Y577 | Phosphorylation | Uniprot | |
| S620 | Phosphorylation | Uniprot | |
| K643 | Ubiquitination | Uniprot | |
| S664 | Phosphorylation | Uniprot | |
| T671 | Phosphorylation | Uniprot | |
| Y693 | Phosphorylation | Uniprot | |
| T695 | Phosphorylation | Uniprot |
研究背景
Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity).
Mitochondrion outer membrane>Single-pass type III membrane protein. Peroxisome membrane>Single-pass type III membrane protein. Microsome membrane>Single-pass type III membrane protein. Endoplasmic reticulum membrane>Single-pass type III membrane protein.
Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas.
Belongs to the ATP-dependent AMP-binding enzyme family.
研究領域
· Cellular Processes > Transport and catabolism > Peroxisome. (View pathway)
· Cellular Processes > Cell growth and death > Ferroptosis. (View pathway)
· Metabolism > Lipid metabolism > Fatty acid biosynthesis.
· Metabolism > Lipid metabolism > Fatty acid degradation.
· Metabolism > Global and overview maps > Metabolic pathways.
· Metabolism > Global and overview maps > Fatty acid metabolism.
· Organismal Systems > Endocrine system > PPAR signaling pathway.
· Organismal Systems > Endocrine system > Adipocytokine signaling pathway.
参考文献
Application: WB Species: Mice Sample: liver tissue
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