GBP5 Antibody - #DF9568
| 製品: | GBP5 Antibody |
| カタログ: | DF9568 |
| タンパク質の説明: | Rabbit polyclonal antibody to GBP5 |
| アプリケーション: | WB |
| 反応性: | Human |
| 分子量: | 67 kDa; 67kD(Calculated). |
| ユニプロット: | Q96PP8 |
| RRID: | AB_2842764 |
製品説明
*The optimal dilutions should be determined by the end user.
*Tips:
WB: For western blot detection of denatured protein samples. IHC: For immunohistochemical detection of paraffin sections (IHC-p) or frozen sections (IHC-f) of tissue samples. IF/ICC: For immunofluorescence detection of cell samples. ELISA(peptide): For ELISA detection of antigenic peptide.
引用形式: Affinity Biosciences Cat# DF9568, RRID:AB_2842764.
折りたたみ／展開
GBP 5; GBP TA antigen; GBP-5; GBP-TA antigen; GBP5; GBP5_HUMAN; GTP binding protein 5; GTP-binding protein 5; Guanine nucleotide binding protein 5; Guanine nucleotide-binding protein 5; Guanylate binding protein 5; Guanylate-binding protein 5; UNQ2427/PRO4987;
免疫原
- Q96PP8 GBP5_HUMAN:
- Protein BLAST With
- NCBI/
- ExPASy/
- Uniprot
MALEIHMSDPMCLIENFNEQLKVNQEALEILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKNKGFSVASTVQSHTKGIWIWCVPHPNWPNHTLVLLDTEGLGDVEKADNKNDIQIFALALLLSSTFVYNTVNKIDQGAIDLLHNVTELTDLLKARNSPDLDRVEDPADSASFFPDLVWTLRDFCLGLEIDGQLVTPDEYLENSLRPKQGSDQRVQNFNLPRLCIQKFFPKKKCFIFDLPAHQKKLAQLETLPDDELEPEFVQQVTEFCSYIFSHSMTKTLPGGIMVNGSRLKNLVLTYVNAISSGDLPCIENAVLALAQRENSAAVQKAIAHYDQQMGQKVQLPMETLQELLDLHRTSEREAIEVFMKNSFKDVDQSFQKELETLLDAKQNDICKRNLEASSDYCSALLKDIFGPLEEAVKQGIYSKPGGHNLFIQKTEELKAKYYREPRKGIQAEEVLQKYLKSKESVSHAILQTDQALTETEKKKKEAQVKAEAEKAEAQRLAAIQRQNEQMMQERERLHQEQVRQMEIAKQNWLAEQQKMQEQQMQEQAAQLSTTFQAQNRSLLSELQHAQRTVNNDDPCVLL
PTMs - Q96PP8 基板として
| Site | PTM Type | Enzyme | Source |
|---|---|---|---|
| S52 | Phosphorylation | Uniprot | |
| S157 | Phosphorylation | Uniprot | |
| K226 | Acetylation | Uniprot | |
| K380 | Ubiquitination | Uniprot | |
| K389 | Ubiquitination | Uniprot | |
| K533 | Ubiquitination | Uniprot | |
| S565 | Phosphorylation | Uniprot |
研究背景
As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, agents. Hydrolyzes GTP, but in contrast to other family members, does not produce GMP.
Isoprenylation is required for proper subcellular location.
Cytoplasm. Golgi apparatus membrane>Lipid-anchor.
Expressed in peripheral blood monocytes (at protein level).
Homodimer. Heterodimer with other family members, including GBP1, GBP2, GBP3 and GBP4. Dimerization is nucleotide-dependent; isoform 1 and isoform 2 form dimers when GTP-bound. GDP-bound isoform 2 is monomeric, while isoform 1 remains dimeric. Dimerization regulates subcellular location. May also form tetramers (dimer of dimers) in the presence of GTP. Interacts with NLRP3, possibly in its tetrameric form, and promotes PYCARD/ASC polymerization.
Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.
研究領域
· Organismal Systems > Immune system > NOD-like receptor signaling pathway. (View pathway)
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